Kammerdiener Leah L, Speiser Jaime Lynn, Aquavella James V, Harissi-Dagher Mona, Dohlman Claes H, Chodosh James, Ciolino Joseph B
Department of Ophthalmology, Flaum Eye Institute, University of Rochester, Rochester, New York, USA Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA.
Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Br J Ophthalmol. 2016 Apr;100(4):549-52. doi: 10.1136/bjophthalmol-2014-306396. Epub 2015 Aug 14.
To evaluate associations between preoperative diagnosis, soft contact lens (SCL) retention and complications.
A retrospective chart review was conducted of 92 adult patients (103 eyes) who received a Boston keratoprosthesis type I at the Massachusetts's Eye and Ear Infirmary or the Flaum Eye Institute. Records were reviewed for preoperative diagnosis, SCL retention and subsequent complications. Preoperative categories included 16 autoimmune (Stevens-Johnson syndrome, ocular cicatricial pemphigoid, rheumatoid arthritis and uveitis), 9 chemical injury and 67 'other' (aniridia, postoperative infection, dystrophies, keratopathies) patients.
50% of the lenses had been lost the first time after about a year. A subset (n=17) experienced more than 2 SCL losses per year; this group is comprised of 1 patient with autoimmune diseases, 2 patients with chemical injuries and 14 patients with 'other' diseases. The preoperative diagnosis was not predictive of contact lens retention. However, multivariate analysis demonstrated that the absence of a contact lens was an independent risk factor for postoperative complications, such as corneal melts with or without aqueous humour leak/extrusion and infections.
Presence of a contact lens after Boston keratoprosthesis implantation decreases the risk of postoperative complications; this has been clinically experienced by ophthalmologists, but never before has the benefit of contact lens use in this patient population been statistically documented.
评估术前诊断、软性隐形眼镜(SCL)留存情况与并发症之间的关联。
对在马萨诸塞州眼耳医院或弗劳姆眼科研究所接受I型波士顿人工角膜植入术的92例成年患者(103只眼)进行回顾性病历审查。审查记录以了解术前诊断、SCL留存情况及随后的并发症。术前类别包括16例自身免疫性疾病(史蒂文斯-约翰逊综合征、瘢痕性类天疱疮、类风湿性关节炎和葡萄膜炎)、9例化学伤患者和67例“其他”(无虹膜、术后感染、营养不良、角膜病变)患者。
50%的镜片在大约一年后首次丢失。一个亚组(n = 17)每年经历超过2次SCL丢失;该组包括1例自身免疫性疾病患者、2例化学伤患者和14例“其他”疾病患者。术前诊断不能预测隐形眼镜的留存情况。然而,多因素分析表明,未佩戴隐形眼镜是术后并发症的独立危险因素,如伴有或不伴有房水渗漏/挤出及感染的角膜溶解。
波士顿人工角膜植入术后佩戴隐形眼镜可降低术后并发症风险;眼科医生在临床上已有此经验,但此前从未有统计学记录证明该患者群体使用隐形眼镜的益处。