注意缺陷多动障碍患儿血清25-羟维生素D水平
[Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder].
作者信息
Shang-Guan Li-Li, Zhao Ya-Ru
机构信息
Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2015 Aug;17(8):837-40.
OBJECTIVE
To examine serum 25-hydroxyvitamin D levels in children with attention deficit hyperactivity disorder (ADHD) and to explore the relationship between vitamin D level and ADHD.
METHODS
Ninety-seven children with ADHD who were diagnosed according to DSM-V were selected as the ADHD group, including 46 cases of ADHD-I, 10 cases of ADHD-HI, and 41 cases of ADHD-C. Ninety-seven healthy children served as the control group. Serum levels of 25-hydroxyvitamin D were measured using electrochemiluminescence immunoassay.
RESULTS
Mean serum levels of 25-hydroxyvitamin D in the ADHD group (17±7 ng/mL) were significantly lower than in the control group (23±8 ng/mL; P<0.01). The serum levels of 25-hydroxyvitamin D in the three subtypes groups of ADHD (ADHD-I, ADHD-HI, and ADHD-C) were all lower than in the control group (P<0.05). The rates of vitamin D insufficiency, deficiency or normal in the ADHD group were different from the control group (P<0.01). The distributions of vitamin D levels in the three subtypes groups of ADHD were all different from the control group (P<0.05).
CONCLUSIONS
Serum levels of 25-hydroxyvitamin D in children with ADHD are lower than in healthy children, suggesting vitamin D level might be related to ADHD.
目的
检测注意缺陷多动障碍（ADHD）患儿血清25-羟维生素D水平，探讨维生素D水平与ADHD之间的关系。
方法
选取97例根据《精神疾病诊断与统计手册》第5版（DSM-V）诊断为ADHD的患儿作为ADHD组，其中注意缺陷为主型（ADHD-I）46例、多动/冲动为主型（ADHD-HI）10例、混合型（ADHD-C）41例。选取97例健康儿童作为对照组。采用电化学发光免疫分析法检测血清25-羟维生素D水平。
结果
ADHD组血清25-羟维生素D平均水平（17±7 ng/mL）显著低于对照组（23±8 ng/mL；P<0.01）。ADHD三个亚型组（ADHD-I、ADHD-HI和ADHD-C）的血清25-羟维生素D水平均低于对照组（P<0.05）。ADHD组维生素D不足、缺乏或正常的发生率与对照组不同（P<0.01）。ADHD三个亚型组的维生素D水平分布均与对照组不同（P<0.05）。
结论
ADHD患儿血清25-羟维生素D水平低于健康儿童，提示维生素D水平可能与ADHD有关。
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