Benkendorff Kirsten, Rudd David, Nongmaithem Bijayalakshmi Devi, Liu Lei, Young Fiona, Edwards Vicki, Avila Cathy, Abbott Catherine A
Marine Ecology Research Centre, School of Environment, Science and Engineering, Southern Cross University, G.P.O. Box 157, Lismore, NSW 2480, Australia.
School of Biological Sciences, Flinders University, G.P.O. Box 2100, Adelaide 5001, Australia.
Mar Drugs. 2015 Aug 18;13(8):5237-75. doi: 10.3390/md13085237.
Marine molluscs from the family Muricidae hold great potential for development as a source of therapeutically useful compounds. Traditionally known for the production of the ancient dye Tyrian purple, these molluscs also form the basis of some rare traditional medicines that have been used for thousands of years. Whilst these traditional and alternative medicines have not been chemically analysed or tested for efficacy in controlled clinical trials, a significant amount of independent research has documented the biological activity of extracts and compounds from these snails. In particular, Muricidae produce a suite of brominated indoles with anti-inflammatory, anti-cancer and steroidogenic activity, as well as choline esters with muscle-relaxing and pain relieving properties. These compounds could explain some of the traditional uses in wound healing, stomach pain and menstrual problems. However, the principle source of bioactive compounds is from the hypobranchial gland, whilst the shell and operculum are the main source used in most traditional remedies. Thus further research is required to understand this discrepancy and to optimise a quality controlled natural medicine from Muricidae.
骨螺科的海洋软体动物作为治疗用化合物的来源具有巨大的开发潜力。这些软体动物传统上以生产古代染料泰尔紫而闻名，它们也是一些已被使用数千年的珍稀传统药物的基础。虽然这些传统药物和替代药物尚未经过化学分析或在对照临床试验中进行疗效测试，但大量独立研究记录了这些蜗牛提取物和化合物的生物活性。特别是，骨螺科产生一系列具有抗炎、抗癌和类固醇生成活性的溴化吲哚，以及具有肌肉松弛和止痛特性的胆碱酯。这些化合物可以解释其在伤口愈合、胃痛和月经问题方面的一些传统用途。然而，生物活性化合物的主要来源是鳃下腺，而贝壳和厣是大多数传统药物中使用的主要来源。因此，需要进一步研究以了解这种差异，并优化来自骨螺科的质量可控的天然药物。
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