Karpov Yuri, Khomitskaya Yunona
Russian Cardiology Research and Production Complex, Moscow, Russian Federation.
AstraZeneca, Moscow, Russian Federation.
Cardiovasc Diabetol. 2015 Aug 25;14:115. doi: 10.1186/s12933-015-0268-2.
Data regarding the prevalence of hypertriglyceridemia in the Russian population are lacking, despite triglyceride (TG)-mediated pathways being causal in cardiovascular disease. The prevalence of mixed dyslipidemia and severe hypertriglyceridemia in the Russian population (PROMETHEUS) was undertaken to address this gap.
This was an observational, cross-sectional retrospective study. Data from adults with a full/partial lipoprotein record who had blood analyses done at an INVITRO laboratory in Russia between January 1, 2011 and December 31, 2013 were analyzed. The primary endpoint was the prevalence of hypertriglyceridemia (TG ≥ 1.7 mmol/L); secondary endpoints included prevalence of borderline high, high, and very high TG and severe hypertriglyceridemia, defined as a TG level of 1.7 to <2.3, 2.3 to <5.6, ≥5.6, and ≥10.0 mmol/L, respectively. Statistical analyses involved the Wilcoxon and the Chi square tests. Correlations between log-transformed TG and low- and high-density lipoprotein cholesterol (LDL-C and HDL-C) and total cholesterol (TC) were assessed. The correlation between glycated hemoglobin (HbA1c) and TG levels in a nested sample of subjects with HbA1c and TG data was also assessed using a log-linear model.
The full dataset and nested sample comprised 357,072 and 54,602 individuals, respectively. Prevalence of hypertriglyceridemia, borderline high TG, high TG, very high TG, and severe hypertriglyceridemia in the full dataset was 29.2, 16.2, 12.9, 0.11, and 0.011%, respectively; corresponding rates in the nested sample were 19.0, 17.2, 0.25, and 0.016%, respectively. TG levels were 16.4% higher in males versus females; males had a greater risk of hypertriglyceridemia (risk ratio 1.25; 95% CI 1.24, 1.26; P < 0.0001). Prevalence of hypertriglyceridemia increased with age, peaking at 40-49 years in males (42.8%) and 60-69 years in females (34.4%); a 0.61% increase in TG levels for each year of life was predicted. Hypertriglyceridemia prevalence increased over time. Correlations between TG and LDL-C, HDL-C, TC, and HbA1c (nested sample only) were observed.
Almost one-third of Russians have hypertriglyceridemia, but severe disease (TG ≥ 10.0 mmol/L) is rare. Although the risk of hypertriglyceridemia was greater in males versus females, its prevalence increased with age, regardless of sex. TG was associated with HbA1c, LDL-C, HDL-C, and TC.
尽管甘油三酯（TG）介导的途径是心血管疾病的病因，但俄罗斯人群中高甘油三酯血症患病率的数据仍然缺乏。开展俄罗斯人群混合性血脂异常和重度高甘油三酯血症患病率研究（PROMETHEUS）以填补这一空白。
这是一项观察性横断面回顾性研究。分析了2011年1月1日至2013年12月31日期间在俄罗斯的INVITRO实验室进行血液分析且有完整/部分脂蛋白记录的成年人的数据。主要终点是高甘油三酯血症（TG≥1.7 mmol/L）的患病率；次要终点包括临界高、高、非常高TG以及重度高甘油三酯血症的患病率，分别定义为TG水平为1.7至<2.3、2.3至<5.6、≥5.6和≥10.0 mmol/L。统计分析采用Wilcoxon检验和卡方检验。评估了对数转换后的TG与低密度和高密度脂蛋白胆固醇（LDL-C和HDL-C）以及总胆固醇（TC）之间的相关性。还使用对数线性模型评估了糖化血红蛋白（HbA1c）与有HbA1c和TG数据的嵌套样本中TG水平之间的相关性。
完整数据集和嵌套样本分别包含357,072人和54,602人。完整数据集中高甘油三酯血症、临界高TG、高TG、非常高TG和重度高甘油三酯血症的患病率分别为29.2%、16.2%、12.9%、0.11%和0.011%；嵌套样本中的相应患病率分别为19.0%、17.2%、0.25%和0.016%。男性的TG水平比女性高16.4%；男性患高甘油三酯血症的风险更大（风险比1.25；95%CI 1.24，1.26；P<0.0001）。高甘油三酯血症的患病率随年龄增加，在男性40 - 49岁时达到峰值（42.8%），女性60 - 69岁时达到峰值（34.4%）；预计每增加一岁TG水平增加0.61%。高甘油三酯血症患病率随时间增加。观察到TG与LDL-C、HDL-C、TC和HbA1c（仅嵌套样本）之间存在相关性。
近三分之一的俄罗斯人患有高甘油三酯血症，但严重疾病（TG≥10.0 mmol/L）很少见。尽管男性患高甘油三酯血症的风险高于女性，但其患病率随年龄增加，与性别无关。TG与HbA1c、LDL-C、HDL-C和TC相关。
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