Grace Elsie L, Burgio Louis D, Allen Rebecca S, DeCoster Jamie, Aiello Allison E, Algase Donna L
a Center for Social Epidemiology and Population Health, School of Public Health , University of Michigan , Ann Arbor , MI , USA.
b School of Social Work , University of Michigan , Ann Arbor , MI , USA.
Aging Ment Health. 2016 Dec;20(12):1297-1304. doi: 10.1080/13607863.2015.1075960. Epub 2015 Aug 25.
The current practice of prescribing psychotropic medication for the management of dementia-related behavioral disturbances is under substantial debate. Using Pearlin's stress process model as theoretical underpinning, the aim of this investigation is to identify caregiver and care recipient characteristics as predictors of anxiolytic, antipsychotic, and antidepressant use among community-dwelling dementia patients. We hypothesized that caregiving burden and patient characteristics, particularly behavior disturbances and pain, would be positively associated with psychotropic medication use.
Data for this exploratory, cross-sectional study were drawn from the baseline assessment of the Resources for Enhancing Alzheimer's Caregiver Health II trial. Only participants with full baseline information were examined (N = 598). Caregiver characteristics, such as confidence managing problematic behaviors, and care recipient characteristics including pain, problem behaviors, cognitive impairment, and functional impairment, were examined in relation to care recipient psychotropic medication use.
Contrary to our hypothesis, behavioral disturbances and burden associated with these disturbances were not significantly associated with psychotropic use. Rather, caregiver characteristics such as race and overall vigilance, and care recipient characteristics such as cognitive status, functional status, and pain were significantly associated with the use of psychotropic medication. Findings differed by class of medication.
These exploratory findings suggest the utility of a holistic approach to understanding the factors associated with pharmacotherapy among community-dwelling elders with dementia. Significant associations between caregiver characteristics and care recipient psychotropic medication use suggest that educating caregivers in non-pharmacologic strategies hold promise for a more balanced biopsychosocial approach to maintaining dementia patients in the community.
目前使用精神药物治疗痴呆相关行为障碍的做法存在很大争议。本研究以皮尔林的压力过程模型为理论基础,旨在确定照顾者和受照顾者的特征,作为社区居住痴呆患者使用抗焦虑药、抗精神病药和抗抑郁药的预测因素。我们假设照顾负担和患者特征,特别是行为障碍和疼痛,与精神药物的使用呈正相关。
本探索性横断面研究的数据来自“增强阿尔茨海默病照顾者健康II”试验的基线评估。仅对具有完整基线信息的参与者进行检查(N = 598)。研究了照顾者特征(如处理问题行为的信心)和受照顾者特征(包括疼痛、问题行为、认知障碍和功能障碍)与受照顾者精神药物使用的关系。
与我们的假设相反,行为障碍以及与这些障碍相关的负担与精神药物使用没有显著关联。相反,照顾者特征(如种族和总体警觉性)和受照顾者特征(如认知状态、功能状态和疼痛)与精神药物的使用显著相关。不同类型药物的研究结果有所不同。
这些探索性结果表明,采用整体方法来理解社区居住痴呆老年人药物治疗相关因素具有实用性。照顾者特征与受照顾者精神药物使用之间的显著关联表明,对照顾者进行非药物策略教育有望实现更平衡的生物心理社会方法,以将痴呆患者维持在社区中。