美国鼻咽癌患者发生第二原发性恶性肿瘤的风险：一项基于人群的研究。
Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population-based study.
作者信息
Chan Jason Y K, Gooi Zhen, Mydlarz Wojciech K, Agrawal Nishant
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E1130-6. doi: 10.1002/hed.24173. Epub 2015 Aug 28.
BACKGROUND
The purpose of this study was to evaluate the incidence of second primary malignancies in patients diagnosed with an index nasopharyngeal carcinoma (NPC) in the United States.
METHODS
The cohort was assembled from the Surveillance, Epidemiology, and End Results (SEER) database with a primary NPC between 1973 and 2005.
RESULTS
There was a 47% increased risk of second primary malignancy. The sites with increased risk include the oral cavity and pharynx (standardized incidence ratio [SIR] = 7.11; 95% confidence interval [CI] = 5.21-9.49), esophagus (SIR = 3.50; 95% CI = 1.68-6.44), nose, nasal cavity, and middle ear (SIR = 15.54; 95% CI = 5.70-33.83), and lung and bronchus (SIR = 2.39; 95% CI = 1.91-2.96).
CONCLUSION
Patients with NPC are likely at a significant risk for second primary malignancies, most notably in the oral cavity and pharynx, which is most likely related to genetic susceptibility, increased surveillance, and treatment effects. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1130-E1136, 2016.
背景
本研究旨在评估美国确诊为原发性鼻咽癌（NPC）患者的第二原发性恶性肿瘤的发生率。
方法
该队列由监测、流行病学和最终结果（SEER）数据库中1973年至2005年间患有原发性NPC的患者组成。
结果
第二原发性恶性肿瘤的风险增加了47%。风险增加的部位包括口腔和咽部（标准化发病率[SIR]=7.11；95%置信区间[CI]=5.21-9.49）、食管（SIR=3.50；95%CI=1.68-6.44）、鼻、鼻腔和中耳（SIR=15.54；95%CI=5.70-33.83）以及肺和支气管（SIR=2.39；95%CI=1.91-2.96）。
结论
NPC患者很可能有发生第二原发性恶性肿瘤的显著风险，最明显的是在口腔和咽部，这很可能与遗传易感性、加强监测和治疗效果有关。©2015威利期刊公司。《头颈》38：E1130-E1136，2016年。
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