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基于中苯基-2,5-噻吩连接的卟啉低聚物和聚合物的光敏剂单线态氧产生效率的合成与研究

Synthesis and investigation of singlet oxygen production efficiency of photosensitizers based on meso-phenyl-2,5-thienylene linked porphyrin oligomers and polymers.

作者信息

Khan Rehan, Idris Muazzam, Tuncel Dönüs

机构信息

Department of Chemistry, Bilkent University, Bilkent, Ankara, 06800, Turkey.

出版信息

Org Biomol Chem. 2015 Nov 14;13(42):10496-504. doi: 10.1039/c5ob01435b. Epub 2015 Sep 2.

DOI:10.1039/c5ob01435b
PMID:26332671
Abstract

Three new Zn(ii)-, oligo- and poly(2,5-thienylene)-linked porphyrins, bearing multiple triethylene glycol (TEG) groups, on all meso aryl positions were synthesized via Stille and Suzuki coupling reactions and their photophysical properties as well as singlet oxygen generation efficiencies have been investigated to elucidate the possibility of their use as a photosensitizer for photodynamic therapy (PDT) and photodynamic inactivation of bacteria.

摘要

通过Stille和Suzuki偶联反应合成了三种新的在所有中位芳基位置带有多个三甘醇(TEG)基团的锌(II)、寡聚和聚(2,5-噻吩撑)连接的卟啉,并研究了它们的光物理性质以及单线态氧生成效率,以阐明它们用作光动力疗法(PDT)和细菌光动力灭活的光敏剂的可能性。

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