播散性黑色素瘤细胞借助钙波移动。
Disseminating Melanoma Cells Surf on Calcium Waves.
作者信息
Sun Jianwei, Lin Shengchen, Keeley Tyler, Yang Shengyu
机构信息
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
出版信息
Mol Cell Oncol. 2015;2(4). doi: 10.1080/23723556.2014.1002714.
Abstract
Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study we investigated the mechanism underlying calcium-mediated melanoma invasion and metastasis, and discovered that hyperactive Ca oscillation in melanoma cells promoted invasion and metastasis through promoting invadopodium formation and extracellular matrix remodeling.
摘要
钙信号失调越来越多地被认为与肿瘤扩散和进展有关。在最近的一项研究中，我们研究了钙介导的黑色素瘤侵袭和转移的潜在机制，发现黑色素瘤细胞中过度活跃的钙振荡通过促进侵袭伪足形成和细胞外基质重塑来促进侵袭和转移。
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