类胡萝卜素、维生素A、维生素C、维生素E、叶酸与女性自我报告的听力损失风险
Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women.
作者信息
Curhan Sharon G, Stankovic Konstantina M, Eavey Roland D, Wang Molin, Stampfer Meir J, Curhan Gary C
机构信息
Channing Division of Network Medicine and Harvard Medical School, Boston MA
Eaton-Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA; Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard and Massachusetts Institute of Technology, Boston, MA;
出版信息
Am J Clin Nutr. 2015 Nov;102(5):1167-75. doi: 10.3945/ajcn.115.109314. Epub 2015 Sep 9.
BACKGROUND
Higher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited.
OBJECTIVE
We prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women.
DESIGN
This prospective cohort study followed 65,521 women in the Nurses' Health Study II from 1991 to 2009. Baseline and updated information obtained from validated biennial questionnaires was used in Cox proportional hazards regression models to examine independent associations between nutrient intake and self-reported hearing loss.
RESULTS
After 1,084,598 person-years of follow-up, 12,789 cases of incident hearing loss were reported. After multivariable adjustment, we observed modest but statistically significant inverse associations between higher intake of β-carotene and β-cryptoxanthin and risk of hearing loss. In comparison with women in the lowest quintile of intake, the multivariable-adjusted RR of hearing loss among women in the highest quintile was 0.88 (95% CI: 0.81, 0.94; P-trend < 0.001) for β-carotene and 0.90 (95% CI: 0.84, 0.96; P-trend < 0.001) for β-cryptoxanthin. In comparison with women with folate intake 200-399 μg/d, very low folate intake (<200 μg/d) was associated with higher risk (RR: 1.19; 95% CI: 1.01, 1.41), and higher intake tended to be associated with lower risk (P-trend = 0.04). No significant associations were observed for intakes of other carotenoids or vitamin A. Higher vitamin C intake was associated with higher risk; in comparison with women with intake <75 mg/d, the RR among women with vitamin C intake ≥1000 mg/d (mainly supplemental) was 1.22 (95% CI: 1.06, 1.42; P-trend = 0.02). There was no significant trend between intake of vitamin E intake and risk.
CONCLUSION
Higher intakes of β-carotene, β-cryptoxanthin, and folate, whether total or from diet, are associated with lower risk of hearing loss, whereas higher vitamin C intake is associated with higher risk.
背景
某些维生素摄入量较高可能预防因血管受损和氧化应激导致的耳蜗损伤，从而降低获得性听力损失风险，但相关数据有限。
目的
我们前瞻性研究了类胡萝卜素、维生素A、维生素C、维生素E和叶酸摄入量与女性自我报告的听力损失风险之间的关系。
设计
这项前瞻性队列研究对护士健康研究II中的65521名女性进行了1991年至2009年的随访。从经过验证的两年一次问卷调查中获得的基线和更新信息用于Cox比例风险回归模型，以检验营养素摄入量与自我报告的听力损失之间的独立关联。
结果
经过1084598人年的随访，报告了12789例新发听力损失病例。多变量调整后，我们观察到较高的β-胡萝卜素和β-隐黄质摄入量与听力损失风险之间存在适度但具有统计学意义的负相关。与摄入量处于最低五分位数的女性相比，摄入量处于最高五分位数的女性中，β-胡萝卜素导致听力损失的多变量调整后风险比（RR）为0.88（95%置信区间：0.81，0.94；P趋势<0.001），β-隐黄质为0.90（95%置信区间：0.84，0.96；P趋势<0.001）。与叶酸摄入量为200 - 399μg/d的女性相比，极低的叶酸摄入量（<200μg/d）与较高风险相关（RR：1.19；95%置信区间：1.01，1.41），较高摄入量往往与较低风险相关（P趋势=0.04）。未观察到其他类胡萝卜素或维生素A摄入量与听力损失之间存在显著关联。较高的维生素C摄入量与较高风险相关；与摄入量<75mg/d的女性相比，维生素C摄入量≥1000mg/d（主要为补充剂）的女性的RR为1.22（95%置信区间：1.06，1.42；P趋势=0.02）。维生素E摄入量与风险之间无显著趋势。
结论
较高的β-胡萝卜素、β-隐黄质和叶酸摄入量，无论是总体摄入量还是饮食摄入量，均与较低的听力损失风险相关，而较高的维生素C摄入量与较高风险相关。
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