磺酰胺基团与吡啶酰胺和内酰胺的多组分三元共晶体。
Multicomponent ternary cocrystals of the sulfonamide group with pyridine-amides and lactams.
作者信息
Bolla Geetha, Nangia Ashwini
机构信息
School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Central University P.O., Hyderabad 500046, India.
出版信息
Chem Commun (Camb). 2015 Nov 4;51(85):15578-81. doi: 10.1039/c5cc06475a.
PMID:26355724
Abstract
SMBA was selected as a bifunctional sulfa drug to design ternary cocrystals with pyridine amides and lactam coformers. Supramolecular assembly of five ternary cocrystals of p-sulfonamide benzoic acid with nicotinamide and 2-pyridone is demonstrated and reproducible heterosynthons are identified for crystal engineering.
摘要
选择磺胺甲异噁唑作为双功能磺胺类药物，与吡啶酰胺和内酰胺共形成剂设计三元共晶体。展示了对氨基苯磺酰胺苯甲酸与烟酰胺和2-吡啶酮的五种三元共晶体的超分子组装，并确定了用于晶体工程的可重现的异合成子。
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