Guidolin Diego, Marinaccio Christian, Tortorella Cinzia, Ruggieri Simona, Rizzi Anna, Maiorano Eugenio, Specchia Giorgina, Ribatti Domenico
Department of Molecular Medicine, University of Padova Medical School, University of Padova, Italy.
Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124 Bari, Italy.
Exp Cell Res. 2015 Nov 15;339(1):96-102. doi: 10.1016/j.yexcr.2015.09.004. Epub 2015 Sep 8.
The spatial distribution of mast cells inside the tumor stroma has been little investigated. In this study, we have evaluated tumor mast cells distribution through the analysis of the morphological features of the spatial patterns generated by these cells, including size, shape, and architecture of the cell pattern. We have compared diffuse large B cells lymphoma (DLBCL) and systemic mastocytosis in two different anatomical localizations (lymph nodes for DLBCL and, respectively, bone marrow for mastocytosis). Results have indicated that, despite the high difference in size exhibited by the mast cells patterns in the two conditions, the spatial relationship between the mast cells forming the aggregates resulted similar, characterized by a significant tendency of the mast cells to self-organize in clusters.
肿瘤基质内肥大细胞的空间分布鲜有研究。在本研究中，我们通过分析这些细胞产生的空间模式的形态特征，包括细胞模式的大小、形状和结构，来评估肿瘤肥大细胞的分布。我们比较了两种不同解剖部位的弥漫性大B细胞淋巴瘤（DLBCL）和系统性肥大细胞增多症（分别为DLBCL的淋巴结和肥大细胞增多症的骨髓）。结果表明，尽管在这两种情况下肥大细胞模式呈现出很大的大小差异，但形成聚集体的肥大细胞之间的空间关系相似，其特征是肥大细胞有显著的自我组织成簇的倾向。
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