来自与螳螂相关真菌埃氏炭角菌IFB-TL01的聚酮化合物。
Polyketides from mantis-associated fungus Daldinia eschscholzii IFB-TL01.
作者信息
Wang Gang, Fan Jing-Yang, Zhang Wen-Jing, Hua Cheng-Pin, Chen Chao-Jun, Yan Wei, Ge Hui-Ming, Jiao Rui-Hua, Tan Ren-Xiang
机构信息
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201).
出版信息
Chem Biodivers. 2015 Sep;12(9):1349-55. doi: 10.1002/cbdv.201400414.
Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4-8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM, and its absolute configuration was determined by single crystal X-ray diffraction.
从黑柄炭角菌培养物中分离出三种新的聚酮化合物，分别命名为达丁酮F（1）、结节孢菌素G（2）和达尔马醇C（3），以及五种已知化合物4 - 8。通过广泛的核磁共振（NMR）和质谱（MS）分析阐明了这些新化合物的结构。化合物1对SW480癌细胞表现出中等细胞毒性活性，IC50值为9.59 μM，其绝对构型通过单晶X射线衍射确定。
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