银屑病表皮中高亲和力表皮生长因子受体减少。
Decreased high-affinity epidermal growth factor receptors in psoriatic epidermis.
作者信息
Urano Y, Ikeuchi T, Fujimoto A, Asano T, Arase S, Shigemi F, Takeda K
出版信息
Tokushima J Exp Med. 1989 Dec;36(3-4):53-8.
Using 125I-EGF the distribution of EGF receptors in psoriatic epidermis was autoradiographically examined. Binding sites of 125I-EGF (20 ng/ml) were mainly located at basal and suprabasal cells in normal and uninvolved psoriatic epidermis, whereas they were located at spinous cells as well as at basal and suprabasal cells in affected psoriatic epidermis. Binding of 125I-EGF (1 ng/ml), on the other hand, was observed in normal and uninvolved psoriatic epidermis but not in affected psoriatic epidermis. The majority of EGF receptors in affected psoriatic epidermis were featured by low affinity for EGF.
采用¹²⁵I - 表皮生长因子（EGF）对银屑病表皮中EGF受体的分布进行放射自显影检查。¹²⁵I - EGF（20纳克/毫升）的结合位点主要位于正常和未受累的银屑病表皮的基底细胞和基底上层细胞，而在受累的银屑病表皮中，它们位于棘细胞以及基底细胞和基底上层细胞。另一方面，在正常和未受累的银屑病表皮中观察到¹²⁵I - EGF（1纳克/毫升）的结合，但在受累的银屑病表皮中未观察到。受累的银屑病表皮中的大多数EGF受体对EGF具有低亲和力。
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