Wang Liuyang, Oehlers Stefan H, Espenschied Scott T, Rawls John F, Tobin David M, Ko Dennis C
Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, 27710, USA.
Department of Medicine and the Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC, 27710, USA.
Genome Biol. 2015 Sep 15;16(1):190. doi: 10.1186/s13059-015-0722-1.
Meta-analyses of genome-wide association studies (GWAS) have demonstrated that the same genetic variants can be associated with multiple diseases and other complex traits. We present software called CPAG (Cross-Phenotype Analysis of GWAS) to look for similarities between 700 traits, build trees with informative clusters, and highlight underlying pathways. Clusters are consistent with pre-defined groups and literature-based validation but also reveal novel connections. We report similarity between plasma palmitoleic acid and Crohn's disease and find that specific fatty acids exacerbate enterocolitis in zebrafish. CPAG will become increasingly powerful as more genetic variants are uncovered, leading to a deeper understanding of complex traits. CPAG is freely available at www.sourceforge.net/projects/CPAG/.
全基因组关联研究（GWAS）的荟萃分析表明，相同的基因变异可能与多种疾病及其他复杂性状相关。我们展示了一款名为CPAG（全基因组关联研究的跨表型分析）的软件，用于寻找700种性状之间的相似性、构建具有信息丰富的聚类的树，并突出潜在的通路。聚类结果与预定义组和基于文献的验证一致，但也揭示了新的联系。我们报告了血浆棕榈油酸与克罗恩病之间的相似性，并发现特定脂肪酸会加剧斑马鱼的小肠结肠炎。随着更多基因变异被发现，CPAG将变得越来越强大，从而更深入地理解复杂性状。CPAG可在www.sourceforge.net/projects/CPAG/上免费获取。
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