Wang Xuanbin, Xiang Longchao, Li Hongliang, Chen Ping, Feng Yibin, Zhang Jingxuan, Yang Nian, Li Fei, Wang Ye, Zhang Quifang, Li Fang, Cao Fengjun
Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China.
Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China.
Int J Mol Sci. 2015 Sep 17;16(9):22527-40. doi: 10.3390/ijms160922527.
The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepatocellular carcinoma (HCC), and provide useful information for carcinogenesis and progression of HCC. Results showed that HMGB1 could induce cell proliferation, differentiation, cell death, angiogenesis, metastasis, inflammation, and enhance immunofunction in in vitro and in vivo HCC models. HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study.
高迁移率族蛋白B1（HMGB1）在癌症中的情况较为复杂，其在不同癌症中的功能尚不确定。本综述旨在从英文电子资源中检索有关HMGB1的文献，分析并总结HMGB1信号通路在肝细胞癌（HCC）中的作用，为HCC的发生和发展提供有用信息。结果表明，在体外和体内HCC模型中，HMGB1可诱导细胞增殖、分化、细胞死亡、血管生成、转移、炎症，并增强免疫功能。HMGB1及其下游受体RAGE、TLRs和TREM-1可能是潜在的抗癌靶点。总之，HMGB1在肿瘤发生中起重要作用，是一个值得进一步研究的新型治疗靶点。
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