Alegría Matos Paola Hilda, Tafur Cabello Kelly Stephanie, Lozano Miranda Adelina, Loza Munarriz Cesar, Lozano Miranda Zenaida
Facultad de Medicina Alberto Hurtado. Universidad Peruana Cayetano Heredia. Lima, PerÚ.
Departamento de GastroenterologÍa. Hospital Nacional Arzobispo Loayza. Lima, PerÚ.
Rev Gastroenterol Peru. 2015 Jul-Sep;35(3):236-42.
Describe the clinical and biochemical characteristics of patients with histopathological findings compatible with steatohepatitis of HNAL patients between 2010-2012. Determine the frequency of alcoholic and non-alcoholic steatohepatitis, presence of metabolic syndrome and other factors associated to non-alcoholic steatohepatitis, its main indications for liver biopsy and biochemical characteristics according to the severity of the histological findings.
We evaluated all histological slides of liver biopsies of the period between 2010-2012, of which, those with the diagnosis of steatohepatitis were selected. Their medical records were then reviewed.
32 patients met inclusion criteria. 28 were female and 4 male, the average age was 49±12 years. Two patients had a history of chronic alcohol consumption, representing the group of alcoholic steatohepatitis. The more frequent clinical finding in patients with NASH (non-alcoholic steatohepatitis), was obesity (37%). 50% of patients had AST/ALT ratio <1.
Among population studied, non-alcoholic steatohepatitis was more common than alcoholic steatohepatitis, being obesity the most associated factor.
描述2010年至2012年间组织病理学检查结果与HNAL患者脂肪性肝炎相符的患者的临床和生化特征。确定酒精性和非酒精性脂肪性肝炎的发生率、代谢综合征的存在情况以及与非酒精性脂肪性肝炎相关的其他因素、肝活检的主要指征以及根据组织学检查结果的严重程度得出的生化特征。
我们评估了2010年至2012年间所有肝活检的组织学切片，从中选取诊断为脂肪性肝炎的切片。然后查阅他们的病历。
32例患者符合纳入标准。女性28例，男性4例，平均年龄为49±12岁。2例患者有慢性饮酒史，属于酒精性脂肪性肝炎组。非酒精性脂肪性肝炎（NASH）患者中最常见的临床发现是肥胖（37%）。50%的患者AST/ALT比值<1。
在所研究的人群中，非酒精性脂肪性肝炎比酒精性脂肪性肝炎更常见，肥胖是最相关的因素。
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