阿尔茨海默病患者中，慢衰退者和快衰退者对β-淀粉样蛋白反应产生白细胞介素-10的情况有所不同。

Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease.

作者信息

Asselineau Delphine, Benlhassan Khadija, Arosio Beatrice, Mari Daniela, Ferri Evelyn, Casati Martina, Gussago Cristina, Tedone Enzo, Annoni Giorgio, Mazzola Paolo, Piette Francois, Belmin Joel, Pariel Sylvie, Bornand Anne, Beaudeux Jean-Louis, Doulazmi Mohamed, Mariani Jean, Bray Dorothy H

机构信息

ImmunoClin Ltd, London, UK.

UPMC University Paris 06, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.

出版信息

J Alzheimers Dis. 2015;46(4):837-42. doi: 10.3233/JAD-142832.

DOI:10.3233/JAD-142832

PMID:26402623

Abstract

We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-γ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.

摘要

我们研究了20例病情进展缓慢的阿尔茨海默病（AD）患者、11例病情进展快速的患者以及20例年龄匹配的对照者中，淀粉样β蛋白（Aβ）刺激外周血单个核细胞（PBMCs）后白细胞介素-10（IL-10）和白细胞介素-6的产生情况。分析了IL-10（-592、-819、-1082位点）、IL-6（-174位点）、转化生长因子-β1（TGF-β1）（-10、-25位点）、干扰素-γ（IFN-γ）（-874位点）和肿瘤坏死因子-α（TNF-α）（-308位点）基因的启动子多态性。Aβ刺激后，病情进展缓慢者的PBMCs中IL-10产生量较高，而病情进展快速者几乎完全消失。证实了AA型IFN-γ低产生基因型与快速进展之间的关联。在更大样本中的研究将阐明这些发现。