Khosravi Arezoo, Sheykhloo Hadi, Karbasi-Afshar Reza, Saburi Amin
Assistant Professor, Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Cardiologist, Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
ARYA Atheroscler. 2015 Mar;11(2):147-52.
Since some degrees of functional mitral regurgitation (MR) may be seen in patients who are candidate for undergoing isolated aortic valve replacement (AVR), determining the effectiveness of AVR surgery on MR rate improvement can be effective in designing a protocol to deal with patients with functional MR. The purpose of this study was to examine the echocardiographic changes after AVR surgery with a focus on changes in MR.
The research was conducted as a before-after observational study on patients hospitalized in Baqiyatallah Hospital, Tehran, Iran, who were undergone AVR surgery between 2011 and 2012. After selecting the patients and obtaining informed consent to participate in the project, transthoracic echocardiographic data were collected by a specialist in Cardiology Echocardiography using ViVid 7 device before and till one week after AVR surgery. The MR rate was measured using methods; including Color Flow Doppler, PISA, Vena Cava Width and Effective Regurgitant Orifice.
Finally, the study was conducted on 85 patients (mean age = 56.23 ± 6.10 years, 27 women = 31.8%). Of 21 patients with preoperative MR more than mild (moderate, mild to moderate), 20 patients (95%) showed at least one degree decrease in MR. Among 64 patients who had mild MR before the surgery, 29 patients improved (45%), that this difference was statistically significant (P < 0.001).
The study results showed that in patients with preoperative MR degree higher than mild, after AVR the MR rate improved 24 times more than those who had preoperative MR degree equivalent to mild and lower. However, these changes are not affected by other echocardiographic changes and patients demographic characteristics.
由于在接受单纯主动脉瓣置换术(AVR)的患者中可能会出现一定程度的功能性二尖瓣反流(MR),确定AVR手术对改善MR发生率的有效性对于设计处理功能性MR患者的方案可能是有效的。本研究的目的是检查AVR手术后的超声心动图变化,重点是MR的变化。
该研究作为一项前后观察性研究,对2011年至2012年在伊朗德黑兰巴奇亚塔拉医院住院并接受AVR手术的患者进行。在选择患者并获得参与项目的知情同意后,由心脏超声专家使用ViVid 7设备在AVR手术前及术后直至一周收集经胸超声心动图数据。使用包括彩色多普勒血流显像、近端等速表面积法、腔静脉宽度和有效反流口面积等方法测量MR发生率。
最终,对85例患者进行了研究(平均年龄=56.23±6.10岁,27例女性=31.8%)。在21例术前MR超过轻度(中度、轻度至中度)的患者中,20例(95%)的MR至少降低了一度。在术前有轻度MR的64例患者中,29例有所改善(45%),这种差异具有统计学意义(P<0.001)。
研究结果表明,术前MR程度高于轻度的患者,AVR术后MR发生率改善的倍数是术前MR程度相当于轻度及以下患者的24倍。然而,这些变化不受其他超声心动图变化和患者人口统计学特征的影响。