一例由“抗 - c”恒河猴抗体引起的急性溶血性输血反应：一份强调输血医学作用的病例报告
An acute hemolytic transfusion reaction due to the "anti-c" rhesus antibody: A case report emphasizing the role of transfusion medicine.
作者信息
Sachan Deepti, Jayakumar Rajeswari, Varghese Joy, Rela Mohamed
机构信息
Department of Transfusion Medicine, Global Health City, Chennai, Tamil Nadu, India.
Department of Hepatology and Liver Transplantation, Global Health City, Chennai, Tamil Nadu, India.
出版信息
Asian J Transfus Sci. 2015 Jul-Dec;9(2):213-5. doi: 10.4103/0973-6247.154256.
Abstract
Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to "anti-c" antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality.
摘要
恒河猴（Rh）介导的溶血性输血反应（HTR）通常由免疫球蛋白G介导且起病延迟。Rh抗体作为急性HTR（AHTR）和血管内溶血的病因仍存在争议。我们在此报告一例53岁男性病例，该患者在输血后3小时内因“抗 - c”抗体发生AHTR，导致丙型肝炎相关慢性肝病患者发生致命的急性肝衰竭。该病例强调了在常规输血前检测中进行抗体筛查的必要性，以及输血医学专家在早期诊断和降低输血相关发病率和死亡率方面的关键作用。
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Korean J Anesthesiol. 2012 Oct;63(4):353-6. doi: 10.4097/kjae.2012.63.4.353. Epub 2012 Oct 12.
2
Anti-AnWj causing acute hemolytic transfusion reactions in a patient with aplastic anemia.抗-Wj 导致再生障碍性贫血患者发生急性溶血性输血反应。
Transfusion. 2012 Jul;52(7):1476-81. doi: 10.1111/j.1537-2995.2011.03477.x. Epub 2012 Jan 10.
3
A mild acute hemolytic transfusion reaction in a patient with alloanti-Ge3: a case report and review of the literature.患者发生 alloanti-Ge3 所致温和型急性溶血性输血反应：病例报告及文献复习
Transfusion. 2011 Sep;51(9):1966-71. doi: 10.1111/j.1537-2995.2011.03093.x. Epub 2011 Mar 10.
4
Red cell alloimmunization in a transfused patient population: a study from a tertiary care hospital in north India.输血患者群体中的红细胞同种免疫：来自印度北部一家三级护理医院的研究
Hematology. 2008 Oct;13(5):313-8. doi: 10.1179/102453308X343419.
5
Recurrent acute hemolytic transfusion reactions by antibodies against Doa antigens, not detected by cross-matching.由针对Doa抗原的抗体引起的反复急性溶血性输血反应，交叉配血未检测到。
Transfusion. 2006 Feb;46(2):244-9. doi: 10.1111/j.1537-2995.2006.00707.x.
6
Clinical significance of anti-Jra: report of two cases and review of the literature.抗Jra的临床意义：两例报告及文献复习
Transfusion. 2004 Feb;44(2):197-201. doi: 10.1111/j.1537-2995.2004.00643.x.
7
Acute intravascular haemolytic transfusion reaction due to anti-c undetected by conventional pretransfusion cross-matching tests.因常规输血前交叉配血试验未检测出抗 - c抗体导致的急性血管内溶血输血反应
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9
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