Chou P, Gonzalez-Crussi F, Mangkornkanok M
Department of Pathology, Children's Memorial Hospital, Chicago, Illinois 60657.
Cancer. 1989 Feb 15;63(4):756-62. doi: 10.1002/1097-0142(19890215)63:4<756::aid-cncr2820630425>3.0.co;2-a.
Two cases of giant cell fibroblastoma in children are described and the available literature on these uncommon neoplasms is summarized. Several local recurrences were noticed in both of our cases, but no metastases occurred. The histologic appearance was distinctive, but no firm conclusions regarding histogenesis could be drawn. Immunostaining methods ruled out a vascular origin. The evidence was not sufficient enough to either confirm or refute a neoplastic histiocytic component of these tumors. The clinical course and pathologic findings suggested that these lesions be classified tentatively with the fibromatoses of childhood.
本文描述了两例儿童巨细胞成纤维细胞瘤,并总结了有关这些罕见肿瘤的现有文献。我们的两个病例均出现了多次局部复发,但未发生转移。组织学表现具有特征性,但关于组织发生学无法得出确凿结论。免疫染色方法排除了血管起源。证据不足以证实或反驳这些肿瘤的肿瘤性组织细胞成分。临床病程和病理结果提示,这些病变可暂归类为儿童纤维瘤病。