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埃塞俄比亚北部接受初始CD4 T细胞评估的成年HIV/AIDS患者中晚期HIV诊断的预测因素:一项病例对照研究

Predictors of Late HIV Diagnosis among Adult People Living with HIV/AIDS Who Undertake an Initial CD4 T Cell Evaluation, Northern Ethiopia: A Case-Control Study.

作者信息

Beyene Melkamu Bedimo, Beyene Habtamu Bedimo

机构信息

Department of Public Health, College of Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

PLoS One. 2015 Oct 8;10(10):e0140004. doi: 10.1371/journal.pone.0140004. eCollection 2015.

Abstract

INTRODUCTION

Early HIV testing and timely initiation of ART is critical for the improved quality of life of PLWHIV. Having identified a higher rates of Late HIV diagnosis, this study was aimed to determine Determinants of late diagnosis of HIV among adult HIV patients in Bahir Dar, Northern Ethiopia.

METHODS

A case control study was conducted between January 2010 to December 2011 at Bahir Dar Felege Hiwot Referral Hospital. The study subjects consisted of 267 cases and 267 controls. Cases were adult people living with HIV/AIDS whose initial CD4 T cell count was < 200/μl of blood. Controls were those with a CD4 T cell count of greater than 200/ μl. Trained staff nurses were involved in data collection using a semi-structured questionnaire. Data was entered and analyzed using SPSS version 20. Descriptive statistics and Binary logistic regression were performed.

RESULTS

Subjects who hold a certificate and above (AOR = 0.26; 95% CI = 0.13. 0.54), being initiated by friends, families and other socials to undertake HIV testing (AOR = 0.65; 95% CI = 0.29, 1.48), who reported a medium and high knowledge score about HIV/AIDS and who undertake HIV testing while visiting a clinic for ANC (AOR = 0.40; 95% CI = 0.19, 0.83) were less likely to be diagnosed late. Subjects who undertake HIV testing due to providers' initiation (AOR = 1.70; 95%CI = 1.08, 2.68), who reported a medium internalized stigma (AOR = 4.94; 95% CI = 3.13, 7.80) and who reported a high internalized stigma score towards HIV/AIDS (AOR = 16.64; 95% CI = 8.29, 33.4) had a high odds of being diagnosed late compared to their counterparts.

CONCLUSION

Internalized stigma, low knowledge level about HIV/AIDS, not to have attended formal education and failure to undertake HIV testing by own initiation were significant determinant factors associated with Late HIV diagnosis. Education about HIV/AIDS, promotion of general education, and encouraging people to motivate their social mates to undertake HIV testing are highly recommended.

摘要

引言

早期艾滋病毒检测和及时启动抗逆转录病毒治疗对于改善艾滋病毒感染者的生活质量至关重要。鉴于已发现晚期艾滋病毒诊断率较高,本研究旨在确定埃塞俄比亚北部巴赫达尔成年艾滋病毒患者中晚期艾滋病毒诊断的决定因素。

方法

2010年1月至2011年12月在巴赫达尔费莱格希沃特转诊医院进行了一项病例对照研究。研究对象包括267例病例和267例对照。病例为初始CD4 T细胞计数低于200/μl血液的艾滋病毒/艾滋病成人患者。对照为CD4 T细胞计数高于200/μl的患者。训练有素的护士使用半结构化问卷参与数据收集。数据使用SPSS 20版录入和分析。进行了描述性统计和二元逻辑回归分析。

结果

持有证书及以上学历的受试者(调整后比值比[AOR]=0.26;95%置信区间[CI]=0.13,0.54)、由朋友、家人和其他社会关系促使进行艾滋病毒检测的受试者(AOR=0.65;95%CI=0.29,1.48)、报告对艾滋病毒/艾滋病有中等和高知识得分的受试者以及在前往诊所进行产前检查时进行艾滋病毒检测的受试者(AOR=0.40;95%CI=0.19,0.83)被晚期诊断的可能性较小。因医护人员促使而进行艾滋病毒检测的受试者(AOR=1.70;95%CI=1.08,2.68)、报告有中等内化耻辱感的受试者(AOR=4.94;95%CI=3.13,7.80)以及报告对艾滋病毒/艾滋病有高内化耻辱感得分的受试者(AOR=16.64;95%CI=8.29,33.4)与对照组相比被晚期诊断的几率较高。

结论

内化耻辱感、对艾滋病毒/艾滋病的低知识水平、未接受正规教育以及未自行主动进行艾滋病毒检测是与晚期艾滋病毒诊断相关的重要决定因素。强烈建议开展关于艾滋病毒/艾滋病的教育、推广普通教育并鼓励人们激励其社会伙伴进行艾滋病毒检测。

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