Suppr超能文献

肠道微生物群:我们所知道和不知道的

Gut Microbiome: What We Do and Don't Know.

作者信息

Cresci Gail A, Bawden Emmy

机构信息

Department of Gastroenterology/Hepatology, Cleveland Clinic, Cleveland, Ohio

Center for Human Nutrition, Cleveland Clinic, Cleveland, Ohio.

出版信息

Nutr Clin Pract. 2015 Dec;30(6):734-46. doi: 10.1177/0884533615609899. Epub 2015 Oct 8.

Abstract

Within the last decade, research regarding the human gut microbiome has exploded. While the gastrointestinal tract was once regarded simply as a digestive organ, new technologies have led the science world to wonder about the impact that the gut microbiota may have on human health and disease. The gut microbiome is now becoming known for its role in metabolism, immune defense, and behavior. From in utero variations to those that rapidly occur post partum, our gut microbiome changes with age, environment, stress, diet, and health status as well as medication exposure. This article reviews what is currently known regarding various influences on the gut microbiome and is meant to encourage the reader to further explore the unknown.

摘要

在过去十年里,关于人类肠道微生物群的研究呈爆发式增长。虽然胃肠道曾一度仅被视为一个消化器官,但新技术让科学界开始思考肠道微生物群可能对人类健康和疾病产生的影响。如今,肠道微生物群因其在新陈代谢、免疫防御和行为方面的作用而为人所知。从子宫内的变化到产后迅速发生的变化,我们的肠道微生物群会随着年龄、环境、压力、饮食、健康状况以及药物接触情况而改变。本文综述了目前已知的关于对肠道微生物群的各种影响,旨在鼓励读者进一步探索未知领域。

相似文献

1
Gut Microbiome: What We Do and Don't Know.
Nutr Clin Pract. 2015 Dec;30(6):734-46. doi: 10.1177/0884533615609899. Epub 2015 Oct 8.
2
The role of the gut microbiome in gastrointestinal cancers.
Cell Signal. 2024 Mar;115:111013. doi: 10.1016/j.cellsig.2023.111013. Epub 2023 Dec 17.
3
The potential impact of gut microbiota on your health:Current status and future challenges.
Asian Pac J Allergy Immunol. 2016 Dec;34(4):249-264. doi: 10.12932/AP0803.
4
The role of the microbiome for human health: from basic science to clinical applications.
Eur J Nutr. 2018 May;57(Suppl 1):1-14. doi: 10.1007/s00394-018-1703-4.
6
Influence of Early Life, Diet, and the Environment on the Microbiome.
Clin Gastroenterol Hepatol. 2019 Jan;17(2):231-242. doi: 10.1016/j.cgh.2018.08.067. Epub 2018 Sep 7.
7
Hepatocellular Carcinoma Immunotherapy and the Potential Influence of Gut Microbiome.
Int J Mol Sci. 2021 Jul 21;22(15):7800. doi: 10.3390/ijms22157800.
8
Smart capsule for targeted proximal colon microbiome sampling.
Acta Biomater. 2022 Dec;154:83-96. doi: 10.1016/j.actbio.2022.09.050. Epub 2022 Sep 24.
9
Inherited nongenetic influences on the gut microbiome and immune system.
Birth Defects Res. 2018 Dec 1;110(20):1494-1503. doi: 10.1002/bdr2.1436.
10
The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants.
Front Cell Infect Microbiol. 2022 Jun 15;12:924119. doi: 10.3389/fcimb.2022.924119. eCollection 2022.

引用本文的文献

2
The Small Intestinal Microbiota and the Gut-Brain Axis in Parkinson's Disease: A Narrative Review.
Biomedicines. 2025 Jul 19;13(7):1769. doi: 10.3390/biomedicines13071769.
3
Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease.
Front Cell Infect Microbiol. 2025 Jul 3;15:1612223. doi: 10.3389/fcimb.2025.1612223. eCollection 2025.
5
Gut microbiota composition is related to anxiety and aggression scores in companion dogs.
Sci Rep. 2025 Jul 8;15(1):24336. doi: 10.1038/s41598-025-06178-4.
7
Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models.
Biology (Basel). 2025 May 23;14(6):593. doi: 10.3390/biology14060593.
8
Microbiome dysbiosis in spinal pathology: Mechanisms, evidence, and research limitations.
Brain Spine. 2025 May 2;5:104272. doi: 10.1016/j.bas.2025.104272. eCollection 2025.
9
The relationship between gut microbiome and human diseases: mechanisms, predisposing factors and potential intervention.
Front Cell Infect Microbiol. 2025 May 6;15:1516010. doi: 10.3389/fcimb.2025.1516010. eCollection 2025.
10
Dietary Habits and Their Influence on the Microbiome and Mental Health in Adolescents.
Nutrients. 2025 Apr 29;17(9):1496. doi: 10.3390/nu17091496.

本文引用的文献

1
Exercise and the microbiota.
Gut Microbes. 2015;6(2):131-6. doi: 10.1080/19490976.2015.1011875. Epub 2015 Mar 24.
2
The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations.
Front Genet. 2014 Nov 21;5:406. doi: 10.3389/fgene.2014.00406. eCollection 2014.
3
Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review.
Am J Clin Nutr. 2014 Dec;100(6):1508-19. doi: 10.3945/ajcn.114.092551. Epub 2014 Nov 5.
4
Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease.
World J Gastroenterol. 2014 Oct 28;20(40):14805-20. doi: 10.3748/wjg.v20.i40.14805.
5
Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.
J Clin Invest. 2014 Oct;124(10):4173-81. doi: 10.1172/JCI72335. Epub 2014 Aug 8.
6
Exercise and associated dietary extremes impact on gut microbial diversity.
Gut. 2014 Dec;63(12):1913-20. doi: 10.1136/gutjnl-2013-306541. Epub 2014 Jun 9.
7
The placenta harbors a unique microbiome.
Sci Transl Med. 2014 May 21;6(237):237ra65. doi: 10.1126/scitranslmed.3008599.
8
Gastrointestinal complaints during exercise: prevalence, etiology, and nutritional recommendations.
Sports Med. 2014 May;44 Suppl 1(Suppl 1):S79-85. doi: 10.1007/s40279-014-0153-2.
9
The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?
J Physiol. 2014 Jul 15;592(14):2989-97. doi: 10.1113/jphysiol.2014.273995. Epub 2014 Apr 22.
10
Dynamics and associations of microbial community types across the human body.
Nature. 2014 May 15;509(7500):357-60. doi: 10.1038/nature13178. Epub 2014 Apr 16.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验