Schölch Sebastian, Rauber Conrad, Weitz Jürgen, Koch Moritz, Huber Peter E
Department of Gastrointestinal, Thoracic and Vascular Surgery; Medizinische Fakultät Carl Gustav Carus; Technische Universität Dresden ; Dresden, Germany ; CCU Molecular and Radiation Oncology; German Cancer Research Center ; Heidelberg, Germany.
Department of Gastroenterology and Hepatology; University Hospital Heidelberg ; Heidelberg, Germany.
Oncoimmunology. 2015 May 7;4(11):e1042201. doi: 10.1080/2162402X.2015.1042201. eCollection 2015 Nov.
Toll-like receptor (TLR) 7/8 ligands act together with radiotherapy and induce profound systemic antitumor immune reactions coordinated by dendritic cells and executed by natural killer (NK) and cytotoxic T cells. Combining TLR ligands and radiation improves both local and distant tumor control and has been shown to be effective against multiple tumor entities.
Toll样受体(TLR)7/8配体与放射疗法协同作用,诱导由树突状细胞协调、自然杀伤(NK)细胞和细胞毒性T细胞执行的深刻全身抗肿瘤免疫反应。联合使用TLR配体和放射疗法可改善局部和远处肿瘤控制,并且已证明对多种肿瘤实体有效。