一种哺乳动物的线粒体自噬靶点。
A mammalian pexophagy target.
作者信息
Subramani Suresh
机构信息
Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, California 92093-0322, USA.
出版信息
Nat Cell Biol. 2015 Nov;17(11):1371-3. doi: 10.1038/ncb3253. Epub 2015 Oct 12.
Abstract
Protein ubiquitylation in mammals is known to trigger selective autophagy of peroxisomes through a process termed pexophagy. The physiological peroxisomal target for pexophagy-related ubiquitylation has been controversial, but two studies have now identified the protein PEX5 as the real candidate.
摘要
已知哺乳动物中的蛋白质泛素化通过一种称为过氧化物酶体自噬的过程触发过氧化物酶体的选择性自噬。过氧化物酶体自噬相关泛素化的生理过氧化物酶体靶点一直存在争议，但现在有两项研究已确定蛋白质PEX5为真正的候选靶点。
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