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以脊柱浆细胞瘤为表现的轻链型多发性骨髓瘤:类似巨细胞瘤的不寻常影像学表现。

Light chain multiple myeloma presenting with spinal plasmacytoma: Unusual radiological appearance mimicking giant cell tumor.

作者信息

Satija Bhawna, Gupta Rajat, Kumar Sanyal, Chandoke Raj

机构信息

Department of Radiodiagnosis, Employees State Insurance Hospital and Post Graduate Institutue of Medical Science and Research, Delhi, India.

出版信息

J Cancer Res Ther. 2015 Jul-Sep;11(3):648. doi: 10.4103/0973-1482.137922.

Abstract

Plasmacytoma, an initial presentation of multiple myeloma, is extremely rare and an unusual cause of spinal cord compression in a young male. A 35-year-old man presented with complaints of progressive weakness and tingling of bilateral lower limbs, severe backache for 3 months, and bladder and bowel incontinence for 1 week duration. Imaging demonstrated lytic destruction of 10 th and 11 th dorsal vertebrae with large soft tissue component and compression of the spinal cord. Biopsy was performed under computed tomography guidance and the histopathology demonstrated presence of plasmacytoma. Serum electrophoresis and bone marrow examination confirmed the diagnosis of light chain multiple myeloma. Though the magnetic resonance imaging the appearance of spinal plasmacytoma is nonspecific, a minibrain appearance has been considered pathognomonic. This case is reported for the unusual radiological appearance of this entity mimicking giant cell tumor.

摘要

浆细胞瘤是多发性骨髓瘤的一种初始表现形式,极为罕见,也是年轻男性脊髓压迫的不寻常病因。一名35岁男性因双侧下肢进行性无力和刺痛、严重背痛3个月以及膀胱和肠道失禁1周前来就诊。影像学检查显示第10和第11胸椎溶骨性破坏,伴有大的软组织成分及脊髓受压。在计算机断层扫描引导下进行了活检,组织病理学显示存在浆细胞瘤。血清电泳和骨髓检查确诊为轻链多发性骨髓瘤。尽管脊髓浆细胞瘤的磁共振成像表现无特异性,但“小脑样外观”被认为具有诊断意义。报道该病例是因其具有类似巨细胞瘤的不寻常放射学表现。

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