Lin Po-Yen, Chien Kuo-Liong, Chang Hong-Ji, Chi Lin-Yang
Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan; Department of Dentistry, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
J Endod. 2015 Dec;41(12):1991-6. doi: 10.1016/j.joen.2015.08.031. Epub 2015 Oct 21.
Root canal treatments (RCTs) aim to eradicate pulpal diseases and save the infected teeth by eliminating microorganisms from the root canal system. Starting but not finishing an RCT can perpetuate a dead space for bacterial growth, which can spread to other sites in the body and develop systemic symptoms. The objective of the present study was to investigate the association between unfinished RCTs and the risk of cardiovascular disease (CVD) using a nationwide population-based database.
A total of 283,590 participants who received at least 1 RCT and with no cardiovascular history before 2005 were recruited and followed until the end of 2011. An unfinished RCT was defined as a tooth on which an RCT was started but with no completion code. Cox proportional hazards models were used to estimate the effect of unfinished RCTs on the risk of CVD.
A total of 3626 participants underwent CVD hospitalization during an average observation period of 6.01 years, thus yielding an overall CVD hospitalization incidence rate of 0.21% per person year. Compared with the participants with no unfinished RCTs, the adjusted CVD hospitalization hazard ratio for the participants with 1 or 2 unfinished RCTs was 1.22 (95% confidence interval, 1.11-1.35) and for those with 3 or more unfinished RCTs, it was 3.61 (95% confidence interval, 2.36-5.51; test for trend, P < .0001).
Participants with unfinished RCTs were associated with a higher risk of CVD hospitalization.
根管治疗（RCTs）旨在根除牙髓疾病，并通过清除根管系统中的微生物来挽救受感染的牙齿。开始但未完成根管治疗会为细菌生长留下一个死腔，细菌可能会扩散到身体的其他部位并引发全身症状。本研究的目的是使用全国性的基于人群的数据库，调查未完成的根管治疗与心血管疾病（CVD）风险之间的关联。
共招募了283,590名在2005年之前接受过至少一次根管治疗且无心血管病史的参与者，并随访至2011年底。未完成的根管治疗被定义为开始了根管治疗但没有完成代码的牙齿。使用Cox比例风险模型来估计未完成的根管治疗对心血管疾病风险的影响。
在平均6.01年的观察期内，共有3626名参与者因心血管疾病住院，因此总体心血管疾病住院发病率为每人每年0.21%。与没有未完成根管治疗的参与者相比，有1或2次未完成根管治疗的参与者调整后的心血管疾病住院风险比为1.22（95%置信区间，1.11 - 1.35），而有3次或更多未完成根管治疗的参与者，该风险比为3.61（95%置信区间，2.36 - 5.51；趋势检验，P <.0001）。
未完成根管治疗的参与者与心血管疾病住院风险较高有关。
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