Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute 10550 N. Torrey Pines Rd., DNC-118, La Jolla, California, 92037.
Ann Clin Transl Neurol. 2015 Oct;2(10):978-83. doi: 10.1002/acn3.251. Epub 2015 Sep 11.
Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin α4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice and also on activated human Jurkat T cells in a manner distinct from nuclear factor erythroid 2-like 2 activation. Our results offer an alternative mechanism for the efficacy of dimethyl fumarate in multiple sclerosis.
富马酸二甲酯是一种用于治疗多发性硬化症和银屑病的口服生物可利用化合物。一种涉及核因子红细胞 2 样 2 激活的机制被提出解释其在多发性硬化症中的疗效。在这里，我们报告富马酸二甲酯抑制实验性自身免疫性脑脊髓炎小鼠循环淋巴细胞和活化的人 Jurkat T 细胞上整合素 α4 的表达，其方式与核因子红细胞 2 样 2 激活不同。我们的结果为富马酸二甲酯在多发性硬化症中的疗效提供了一种替代机制。
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