纳米羟基磷灰石性能扩展的简单途径。

Simple route for nano-hydroxyapatite properties expansion.

作者信息

Rojas L, Olmedo H, García-Piñeres A J, Silveira C, Tasic L, Fraga F, Montero M L

机构信息

Escuela de Química, Universidad de Costa Rica, San José, Costa Rica. Centro de Electroquímica y Energía Química (CELEQ), Universidad de Costa Rica, San José, Costa Rica.

出版信息

Biomed Mater. 2015 Oct 20;10(5):055015. doi: 10.1088/1748-6041/10/5/055015.

DOI:10.1088/1748-6041/10/5/055015

PMID:26481455

Abstract

Simple surface modification of nano-hydroxyapatite, through acid-basic reactions, allows expanding the properties of this material. Introduction of organic groups such as hydrophobic alkyl chains, carboxylic acid, and amide or amine basic groups on the hydroxyapatite surface systematically change the polarity, surface area, and reactivity of hydroxyapatite without modifying its phase. Physical and chemical properties of the new derivative particles were analyzed. The biocompatibility of modified Nano-Hap on Raw 264.7 cells was also assessed.

摘要

通过酸碱反应对纳米羟基磷灰石进行简单的表面改性，可以扩展这种材料的性能。在羟基磷灰石表面引入有机基团，如疏水烷基链、羧酸以及酰胺或胺基碱性基团，能够系统地改变羟基磷灰石的极性、表面积和反应活性，而不改变其物相。对新衍生颗粒的物理和化学性质进行了分析。还评估了改性纳米羟基磷灰石对Raw 264.7细胞的生物相容性。