Turkmen G G, Karçaaltıncaba D, Isık H, Fidancı V, Kaayalp D, Tımur H, Batıoglu S
a Department of Gynecology and Obstetrics , Ankara Education and Research Hospital , Ankara , Turkey.
b Department of Gynecology and Obstetrics , Bülent Ecevit University , Zonguldak , Turkey.
J Obstet Gynaecol. 2016;36(3):347-50. doi: 10.3109/01443615.2015.1065228. Epub 2015 Oct 23.
Early diagnosis of ectopic pregnancy (EP) is important due to life-threatening consequences in the first trimester of pregnancy. In this study we aimed to investigate the role of adenosine deaminase (ADA) activity in the prediction of EP. Forty-one patients with unruptured ectopic pregnancy comprised the case group and forty-two first trimester pregnant women with shown foetal heart beating in ultrasound comprised the control group. The mean ADA level in EP (10.9 ± 3.0 IU/L) was higher than that in control group (9.2 ± 3.6 IU/L) (p = 0.018). Receiver operating characteristics or ROC curve identified ADA value of 10.95 IU/L as optimal threshold for the prediction of EP with 56% sensitivity and 67% specificity. High ADA levels are valuable in the early diagnosis of EP. However more comprehensive studies are required.
由于异位妊娠（EP）在妊娠早期会产生危及生命的后果，因此早期诊断非常重要。在本研究中，我们旨在探讨腺苷脱氨酶（ADA）活性在预测EP中的作用。41例未破裂异位妊娠患者组成病例组，42例超声显示有胎心搏动的孕早期孕妇组成对照组。EP组的ADA平均水平（10.9±3.0 IU/L）高于对照组（9.2±3.6 IU/L）（p = 0.018）。受试者工作特征曲线（ROC曲线）确定ADA值为10.95 IU/L是预测EP的最佳阈值，敏感性为56%，特异性为67%。高ADA水平对EP的早期诊断有价值。然而，还需要更全面的研究。
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