维替泊芬光动力疗法治疗散发性视网膜毛细血管瘤

Verteporfin photodynamic therapy for the treatment of sporadic retinal capillary haemangioblastoma.

作者信息

Hussain R N, Jmor F, Damato B, Heimann H

机构信息

Liverpool Ocular Oncology Service, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK.

出版信息

Photodiagnosis Photodyn Ther. 2015 Dec;12(4):555-60. doi: 10.1016/j.pdpdt.2015.10.008. Epub 2015 Oct 20.

DOI:10.1016/j.pdpdt.2015.10.008

PMID:26497444

Abstract

PURPOSE

To assess the effectivity of photodynamic therapy (PDT) for the treatment of retinal capillary haemangiomas

METHOD

Retrospective case note analysis of all patients with retinal angiomas treated with PDT between 2003 and 2010.

RESULTS

Six eyes of 6 patients (3 male, 3 female) with a mean age of 50 years (range, 23-78) were identified in our database. The follow up period was between 24 and 60 months (mean, 36). Tumor regression was evident in two patients; three tumors showed no demonstrable response to treatment on ophthalmoscopy or ultrasonography and one tumor progressed despite PDT and subsequent cryotherapy. One patient developed retinal neovascularisations following a period of inattendence to our clinic. Visual acuity improved in two patients following PDT, deteriorated in three patients and remained stable in a one patient.

CONCLUSION

The response of retinal haemangioblastomas to PDT is inconsistent. Other treatment modalities ought to be utilized for peripheral lesions, however PDT may be tried in juxtapapillary lesions where radiotherapy or cryotherapy is likely to result in concurrent visual loss.

摘要

目的

评估光动力疗法（PDT）治疗视网膜毛细血管瘤的有效性。

方法

对2003年至2010年间接受PDT治疗的所有视网膜血管瘤患者进行回顾性病例记录分析。

结果

在我们的数据库中确定了6例患者（3男，3女）的6只眼，平均年龄50岁（范围23 - 78岁）。随访期为24至60个月（平均36个月）。两名患者肿瘤明显消退；三名肿瘤在检眼镜或超声检查中对治疗无明显反应，一名肿瘤尽管接受了PDT及后续冷冻治疗仍进展。一名患者在一段时间未到我们诊所就诊后发生视网膜新生血管。两名患者接受PDT后视力改善，三名患者视力恶化，一名患者视力保持稳定。