脑电压门控钠通道转录和翻译后调控的最新进展。
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels.
作者信息
Onwuli Donatus O, Beltran-Alvarez Pedro
机构信息
School of Biological, Biomedical and Environmental Sciences, University of Hull, Hardy Building Cottingham Road, Hull, HU6 7RX, UK.
出版信息
Amino Acids. 2016 Mar;48(3):641-651. doi: 10.1007/s00726-015-2122-y. Epub 2015 Oct 27.
Abstract
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (NaV1.1), SCN2A (NaV1.2), SCN3A (NaV1.3) and SCN8A (NaV1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.
摘要
电压门控钠通道是脑生理学中的重要蛋白质，因为它们产生引发神经元动作电位的钠电流。电压门控钠通道的表达、定位和功能受一系列转录和翻译后机制调控。在此，我们综述对脑电压门控钠通道，特别是SCN1A（NaV1.1）、SCN2A（NaV1.2）、SCN3A（NaV1.3）和SCN8A（NaV1.6），在转录因子、可变剪接和翻译后修饰方面调控的理解。我们的重点强烈集中于最近的研究方向和新产生的知识。
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本文引用的文献
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2
Differential modulation of fast inactivation in cardiac sodium channel splice variants by Fyn tyrosine kinase.
Cell Physiol Biochem. 2015;37(3):825-37. doi: 10.1159/000430211. Epub 2015 Sep 18.
3
Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy.
Neuropharmacology. 2015 Oct;97:113-21. doi: 10.1016/j.neuropharm.2015.05.040. Epub 2015 Jun 15.
4
Clinical and genetic analysis of a family with two rare reflex epilepsies.
Seizure. 2015 Jul;29:90-6. doi: 10.1016/j.seizure.2015.03.020. Epub 2015 Apr 6.
5
Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death.
Circ Res. 2015 Jun 5;116(12):1971-88. doi: 10.1161/CIRCRESAHA.116.305017.
6
CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure.
J Proteome Res. 2015 May 1;14(5):2298-311. doi: 10.1021/acs.jproteome.5b00107. Epub 2015 Apr 13.
7
Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
J Mol Cell Cardiol. 2015 May;82:36-47. doi: 10.1016/j.yjmcc.2015.02.013. Epub 2015 Mar 4.
8
Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.
Biochim Biophys Acta. 2015 Jun;1850(6):1215-23. doi: 10.1016/j.bbagen.2015.02.009. Epub 2015 Feb 23.
9
RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels.
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2859-64. doi: 10.1073/pnas.1414002112. Epub 2015 Feb 17.
10
The Nav1.2 channel is regulated by GSK3.
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