帕金森病与癌症之间的关联：情况愈发复杂。
The associations between Parkinson's disease and cancer: the plot thickens.
作者信息
Feng Danielle D, Cai Waijiao, Chen Xiqun
机构信息
MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA.
出版信息
Transl Neurodegener. 2015 Oct 26;4:20. doi: 10.1186/s40035-015-0043-z. eCollection 2015.
Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson's disease (PD). In recent years however, increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups. This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation. Here, we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings.
流行病学研究支持癌症发生风险与帕金森病（PD）之间存在普遍的负相关关系。然而近年来，越来越多的综合性证据通过不同的时间分析和种族群体表明，PD与癌症之间存在正相关关系。这种正相关关系得到了一些常见基因突变的支持，如SNCA、PARK2、PARK8、ATM、p53、PTEN和MC1R，这些基因突变会导致细胞变化，如线粒体功能障碍、异常蛋白质聚集和细胞周期失调。在此，我们回顾过去十年中PD与癌症关联方面的流行病学和生物学进展，以深入了解近期一些有时相互矛盾的研究结果。
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