阳极感觉神经动作电位：从生理理解到潜在临床应用
Anodal sensory nerve action potentials: From physiological understanding to potential clinical applicability.
作者信息
Leote Joao, Pereira Pedro, Cabib Christopher, Cipullo Federica, Valls-Sole Josep
机构信息
Neurosurgery Department, Hospital Garcia de Orta, Almada, Portugal.
Neurology Department, Hospital Garcia de Orta, Almada, Portugal.
出版信息
Muscle Nerve. 2016 Jun;53(6):897-905. doi: 10.1002/mus.24957. Epub 2016 Mar 1.
INTRODUCTION
Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings.
METHODS
We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied a conditioning stimulus to study potential differences in recovery time.
RESULTS
The anAP was obtained in 33 of 40 healthy subjects (82.5%) and 4 of 20 patients with various types of sensory neuropathies (20%). Changes in stimulus duration and intensity had reciprocal effects on the amplitude of the anAP and the caAP. There were significant differences in recovery time between caAP and anAP after a conditioning stimulus.
CONCLUSION
The caAP and anAP are 2 interdependent waveforms generated by different effects of the same stimulus over axons at the verge of depolarization. Muscle Nerve 53: 897-905, 2016.
引言
在顺向记录中，指神经的低强度电刺激可能会产生一个双峰电位（DPp），该电位由阴极电位（caAP）和阳极电位（anAP）组成。
方法
我们研究了不同强度、持续时间和频率的刺激对caAP和anAP的影响。我们还施加了一个条件刺激来研究恢复时间的电位差异。
结果
40名健康受试者中有33名（82.5%）获得了anAP，20名患有各种类型感觉神经病变的患者中有4名（20%）获得了anAP。刺激持续时间和强度的变化对anAP和caAP的幅度有相互影响。在施加条件刺激后，caAP和anAP的恢复时间存在显著差异。
结论
caAP和anAP是由同一刺激在接近去极化的轴突上产生的不同效应所产生的两个相互依赖的波形。《肌肉与神经》53: 897 - 905, 2016。
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