诊疗纳米颗粒的药代动力学、药效学及毒理学
Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles.
作者信息
Kang Homan, Mintri Shrutika, Menon Archita Venugopal, Lee Hea Yeon, Choi Hak Soo, Kim Jonghan
机构信息
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
出版信息
Nanoscale. 2015 Dec 7;7(45):18848-62. doi: 10.1039/c5nr05264e. Epub 2015 Nov 3.
Abstract
Nanoparticles (NPs) are considered a promising tool in both diagnosis and therapeutics. Theranostic NPs possess the combined properties of targeted imaging and drug delivery within a single entity. While the categorization of theranostic NPs is based on their structure and composition, the pharmacokinetics of NPs are significantly influenced by the physicochemical properties of theranostic NPs as well as the routes of administration. Consequently, altered pharmacokinetics modify the pharmacodynamic efficacy and toxicity of NPs. Although theranostic NPs hold great promise in nanomedicine and biomedical applications, a lack of understanding persists on the mechanisms of the biodistribution and adverse effects of NPs. To better understand the diagnostic and therapeutic functions of NPs, this review discusses the factors that influence the pharmacokinetics, pharmacodynamics and toxicology of theranostic NPs, along with several strategies for developing novel diagnostic and therapeutic modalities.
摘要
纳米颗粒（NPs）被认为是诊断和治疗领域中一种很有前景的工具。诊疗纳米颗粒在单个实体中具备靶向成像和药物递送的综合特性。虽然诊疗纳米颗粒的分类是基于其结构和组成，但纳米颗粒的药代动力学受到诊疗纳米颗粒的物理化学性质以及给药途径的显著影响。因此，改变的药代动力学改变了纳米颗粒的药效学功效和毒性。尽管诊疗纳米颗粒在纳米医学和生物医学应用中具有很大的前景，但对纳米颗粒的生物分布和不良反应机制仍缺乏了解。为了更好地理解纳米颗粒的诊断和治疗功能，本综述讨论了影响诊疗纳米颗粒药代动力学、药效学和毒理学的因素，以及开发新型诊断和治疗方式的几种策略。
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