Song Jee In, Kim Yang-Ki, Hwang Jung Hwa, Yang Hyeon-Jong
a Department of Pediatrics .
b Division of Respiratory and Allergy Medicine , Department of Internal Medicine , and.
J Asthma. 2016;53(4):452-5. doi: 10.3109/02770903.2015.1101135. Epub 2016 Jan 21.
Acute eosinophilic pneumonia (AEP) is a rapid onset and severe respiratory illness characterized by acute febrile respiratory insufficiency, eosinophilic infiltration in the lungs and unique findings on chest imaging. Difficulty in differentiating from other respiratory distress caused by community-acquired pneumonia may result in a delayed diagnosis or treatment with empirical antibiotics.
Sixteen-year-old boy who developed AEP with marked eosinophilia in bronchoalveolar lavage fluid (BALF, 36.6%), decreased diffusion capacity of the lung for carbon monoxide (62%) and unique radiological findings. Although he initially denied tobacco use, on repeated thorough clinical history questioning, he eventually admitted beginning smoking 19 days before the onset of symptoms with gradually increasing frequency.
His symptoms resolved quickly without use of antibiotics after cessation of tobacco and treatment with corticosteroids.
Careful clinical history taking regarding tobacco use combined with early examination of BALF and recognition of unique radiological findings are critical for proper management of AEP.
急性嗜酸性粒细胞性肺炎(AEP)是一种起病迅速且严重的呼吸系统疾病,其特征为急性发热性呼吸功能不全、肺部嗜酸性粒细胞浸润以及胸部影像学的独特表现。难以与社区获得性肺炎引起的其他呼吸窘迫相鉴别可能导致诊断延迟或经验性使用抗生素治疗。
一名16岁男孩患AEP,支气管肺泡灌洗液(BALF)中嗜酸性粒细胞显著增多(36.6%),肺一氧化碳弥散量降低(62%),并有独特的影像学表现。尽管他最初否认吸烟,但在反复详细询问临床病史后,他最终承认在症状出现前19天开始吸烟,且频率逐渐增加。
在戒烟并使用糖皮质激素治疗后,他的症状未使用抗生素便迅速缓解。
仔细询问关于吸烟的临床病史,结合早期BALF检查以及认识独特的影像学表现,对于AEP的恰当管理至关重要。