2型糖尿病患者的癌症发病率：一项基于上海人群的队列研究
Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai.
作者信息
Xu Hui-Lin, Fang Hong, Xu Wang-Hong, Qin Guo-You, Yan Yu-Jie, Yao Bao-Dong, Zhao Nai-Qing, Liu Yi-Nan, Zhang Fen, Li Wei-Xi, Wang Na, Zhou Jie, Zhang Jin-Ling, Zhao Li-Yun, Li Lun-Qiang, Zhao Yan-Ping
机构信息
School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China.
出版信息
BMC Cancer. 2015 Nov 5;15:852. doi: 10.1186/s12885-015-1887-4.
BACKGROUND
Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.
METHODS
A population-based retrospective cohort study including 36,379 T2DM patients was conducted in Minhang District of Shanghai, China, during 2004 to 2010. All T2DM patients were enrolled from the standardized management system based on local electronic information system. Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry. Standardized incidence ratios (SIR) and 95% confidence interval (CI) were used to estimate the risk of cancers among T2DM patients.
RESULTS
Overall crude incidence rate (CIR) of cancers was 955.21 per 105 person-years in men and 829.57 per 105 person-years in women. Increased risk of cancer was found in both gender, with an SIR being 1.28 (95% CI = 1.17-1.38) in men and 1.44 (95% CI =1.32-1.55) in women. Increased risk of colon (SIR = 1.97; 95% CI = 1.49 to 2.46), rectum (1.72; 1.23 to 2.21), prostate (2.87; 2.19 to 3.56), and bladder cancers (1.98, 1.28 to 2.68) were observed in men and elevated risk of colon (1.67; 1.25 to 2.08), breast (1.66; 1.38 to 1.95), and corpus uteri cancers (2.87; 2.03 to 3.71) were observed in women.
CONCLUSIONS
Our results indicate that Chinese patients with T2DM may have an increased risk of some cancers, and the increase may vary by sub-sites of cancers.
背景
2型糖尿病（T2DM）被认为会增加患癌风险。本研究旨在调查中国T2DM患者患常见癌症的风险。
方法
2004年至2010年期间，在中国上海闵行区开展了一项基于人群的回顾性队列研究，纳入36379例T2DM患者。所有T2DM患者均从基于当地电子信息系统的标准化管理系统中招募。通过与上海癌症登记处的记录链接识别新诊断的癌症病例。采用标准化发病率比（SIR）和95%置信区间（CI）来估计T2DM患者患癌风险。
结果
男性癌症总体粗发病率（CIR）为每105人年955.21例，女性为每105人年829.57例。两性患癌风险均增加，男性SIR为1.28（95%CI=1.17-1.38），女性为1.44（95%CI=1.32-1.55）。男性患结肠癌（SIR=1.97；95%CI=1.49至2.46）、直肠癌（1.72；1.23至2.21）、前列腺癌（2.87；2.19至3.56）和膀胱癌（1.98，1.28至2.68）的风险增加，女性患结肠癌（1.67；1.25至2.08）、乳腺癌（1.66；1.38至1.95）和子宫体癌（2.87；2.03至3.71）的风险升高。
结论
我们的结果表明，中国T2DM患者可能患某些癌症的风险增加，且这种增加可能因癌症亚部位而异。
Zotero 插件