透明质酸作为人类疾病的治疗靶点。
Hyaluronan as a therapeutic target in human diseases.
作者信息
Liang Jiurong, Jiang Dianhua, Noble Paul W
机构信息
Department of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Department of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
出版信息
Adv Drug Deliv Rev. 2016 Feb 1;97:186-203. doi: 10.1016/j.addr.2015.10.017. Epub 2015 Nov 2.
Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix and plays an important role in regulating tissue injury and repair, and controlling disease outcomes. The function of hyaluronan depends on its size, location, and interactions with binding partners. While fragmented hyaluronan stimulates the expression of an array of genes by a variety of cell types regulating inflammatory responses and tissue repair, cell surface hyaluronan provides protection against tissue damage from the environment and promotes regeneration and repair. The interactions of hyaluronan and its binding proteins participate in the pathogenesis of many human diseases. Thus, targeting hyaluronan and its interactions with cells and proteins may provide new approaches to developing therapeutics for inflammatory and fibrosing diseases. This review focuses on the role of hyaluronan in biological and pathological processes, and as a potential therapeutic target in human diseases.
细胞外基质的积累和更新是人类疾病中组织损伤、修复和重塑的一个标志。透明质酸是细胞外基质的主要成分，在调节组织损伤和修复以及控制疾病结局方面发挥着重要作用。透明质酸的功能取决于其大小、位置以及与结合伴侣的相互作用。虽然片段化的透明质酸可通过多种调节炎症反应和组织修复的细胞类型刺激一系列基因的表达，但细胞表面的透明质酸可保护组织免受环境损伤，并促进再生和修复。透明质酸与其结合蛋白的相互作用参与了许多人类疾病的发病机制。因此，针对透明质酸及其与细胞和蛋白质的相互作用可能为开发炎症性和纤维化疾病的治疗方法提供新途径。本综述重点关注透明质酸在生物学和病理过程中的作用，以及作为人类疾病潜在治疗靶点的作用。
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