X射线修复交叉互补基因1多态性与胶质瘤风险的关联：基于22项病例对照研究的系统评价和荟萃分析
Association between X-ray repair cross-complementing group 1 gene polymorphisms and glioma risk: a systematic review and meta-analysis based on 22 case-control studies.
作者信息
Li Jiqiang, Chen Qianxue, Liu Baohui, Yang Jian, Shao Lingmin, Wu Tingfeng
机构信息
Department of Neurosurgery, Renmin Hospital, Wuhan University Wuhan 430060, China ; Central Laboratory of Renmin Hospital of Wuhan University Wuhan 430060, China.
Department of Neurosurgery, Renmin Hospital, Wuhan University Wuhan 430060, China.
出版信息
Int J Clin Exp Med. 2015 Aug 15;8(8):11863-80. eCollection 2015.
OBJECTIVES
Glioma is the most common central nervous system tumor. This systematic review and meta-analysis is aimed to systematically assess the association of XRCC1 polymorphisms with the risk of glioma.
METHODS
Such databases as EMbase, PubMed, The Cochrane Library, the China National Knowledge Infrastructure (CNKI) platforms, VIP and WanFang were searched up to April 2015 to collect case-control studies of association between XRCC1 polymorphisms and glioma. Data were extracted and meta-analysis was conducted by using Stata 12.0 softwares.
RESULTS
A total of 22 studies were included in the meta-analysis, including 18503 glioma patients and 24367 controls. The overall data indicated that XRCC1 Arg194Trp (C>T) polymorphism significantly increased glioma risk (allele C versus T: OR=0.72, 95% CI=0.55-0.93, CC versus TT: OR=0.55, 95% CI=0.46-0.67; CC versus CT+TT: OR=0.64, 95% CI=0.45-0.91 and CC+CT vs. TT: OR=0.61, 95% CI=0.51-0.74), especially in Asia ethnicity. XRCC1 Arg280His (G>A) polymorphism has no association with glioma (allele G versus A: OR=1.01, 95% CI=0.83-1.22; GG versus AA: OR=1.07, 95% CI=0.66-1.75; GA versus AA: OR=1.01, 95% CI=0.77-1.32; GG versus GA+AA: OR=1.01, 95% CI=0.84-1.22 and GG+GT versus AA: OR=1.06, 95% CI=0.67-1.69). XRCC1 Arg399Gln (G>A) polymorphism will significantly increase glioma risk in Asian (allele G versus A: OR=0.78, 95% CI= 0.72-0.84; GG versus AA: OR=0.56, 95% CI=0.47-0.66; GA versus AA OR=0.71, 95% CI=0.59-0.84; GG versus GA+AA: OR=0.76, 95% CI=0.68-0.84 and GG+GA vs. AA: OR=0.62, 95% CI=0.53-0.73) but not Caucasian ethnicity. XRCC1 Pro161Leu (C>T), Leu387Leu (G>A), Pro602Thr (C>A), Ser593Arg (C>G) and Glu491Lys (G>A) polymorphisms increased glioma risk in different degrees.
CONCLUSION
This meta-analysis suggested that XRCC1 Arg194Trp and XRCC1 Arg399Gln (G>A) polymorphisms led to susceptibility to glioma in Asian but not Caucasian population. XRCC1 Glu491Lys (G>A), Pro161Leu (C>T), Leu387Leu (G>A), Pro602Thr (C>A), Thr304Ala (A>G) and Ser593Arg (C>G) polymorphisms will increase glioma risk. However, XRCC1 Arg280His (G>A) is irrelevant to the increased or decreased glioma risk.
目的
胶质瘤是最常见的中枢神经系统肿瘤。本系统评价和荟萃分析旨在系统评估XRCC1基因多态性与胶质瘤风险的关联。
方法
检索截至2015年4月的EMbase、PubMed、Cochrane图书馆、中国知网（CNKI）平台、维普和万方等数据库，收集关于XRCC1基因多态性与胶质瘤关联的病例对照研究。提取数据并使用Stata 12.0软件进行荟萃分析。
结果
荟萃分析共纳入22项研究，包括18503例胶质瘤患者和24367例对照。总体数据表明，XRCC1基因的Arg194Trp（C>T）多态性显著增加胶质瘤风险（等位基因C与T比较：OR=0.72，95%CI=0.55-0.93；CC与TT比较：OR=0.55，95%CI=0.46-0.67；CC与CT+TT比较：OR=0.64，95%CI=0.45-0.91；CC+CT与TT比较：OR=0.61，95%CI=0.51-0.74），尤其是在亚洲人群中。XRCC1基因的Arg280His（G>A）多态性与胶质瘤无关联（等位基因G与A比较：OR=1.01，95%CI=0.83-1.22；GG与AA比较：OR=1.07，95%CI=0.66-1.75；GA与AA比较：OR=1.01，95%CI=0.77-1.32；GG与GA+AA比较：OR=1.01，95%CI=0.84-1.22；GG+GT与AA比较：OR=1.06，95%CI=0.67-1.69）。XRCC1基因的Arg399Gln（G>A）多态性在亚洲人群中会显著增加胶质瘤风险（等位基因G与A比较：OR=0.78，95%CI=0.72-0.84；GG与AA比较：OR=0.56，95%CI=0.47-0.66；GA与AA比较：OR=0.71，95%CI=0.59-0.84；GG与GA+AA比较：OR=0.76，95%CI=0.68-0.84；GG+GA与AA比较：OR=0.62，95%CI=0.53-0.73），但在白种人群中无此关联。XRCC1基因的Pro161Leu（C>T）、Leu387Leu（G>A）、Pro602Thr（C>A）、Ser593Arg（C>G）和Glu491Lys（G>A）多态性在不同程度上增加了胶质瘤风险。
结论
本荟萃分析表明，XRCC1基因的Arg194Trp和Arg399Gln（G>A）多态性使亚洲人群而非白种人群易患胶质瘤。XRCC1基因的Glu491Lys（G>A）、Pro161Leu（C>T）、Leu387Leu（G>A）、Pro602Thr（C>A）、Thr304Ala（A>G）和Ser593Arg（C>G）多态性会增加胶质瘤风险。然而，XRCC1基因的Arg280His（G>A）与胶质瘤风险的增加或降低无关。
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