采用新诊断标准诊断的血清阴性视神经脊髓炎谱系疾病患者。
Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria.
机构信息
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
出版信息
Mult Scler. 2016 Sep;22(10):1371-5. doi: 10.1177/1352458515615954. Epub 2015 Nov 9.
BACKGROUND
Recently, new diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) were published.
OBJECTIVE
Our primary aim was to evaluate the usefulness of the new diagnostic criteria in anti-aquaporin 4 (AQP4) antibody-negative cases.
METHODS
Consecutive 471 patients whose anti-AQP4 antibody was measured at Chiba University were reviewed.
RESULTS
Four anti-AQP4 antibody negative-patients, who fulfilled the new diagnostic criteria for NMOSD but not 2006 diagnostic criteria for neuromyelitis optica (NMO), were identified. They showed high cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, which are compatible findings for NMO.
CONCLUSION
The new diagnostic criteria are clinically useful in seronegative NMOSD.
背景
最近，视神经脊髓炎谱系疾病（NMOSD）的新诊断标准已经公布。
目的
我们的主要目的是评估新诊断标准在抗水通道蛋白 4（AQP4）抗体阴性病例中的有用性。
方法
回顾了在千叶大学检测抗 AQP4 抗体的连续 471 例患者。
结果
确定了 4 例抗 AQP4 抗体阴性但符合 NMOSD 新诊断标准但不符合视神经脊髓炎（NMO）2006 诊断标准的患者。他们表现出高脑脊液白细胞介素-6 和神经胶质纤维酸性蛋白水平，缺乏寡克隆带和/或磁共振成像上的云状增强，这些都是 NMO 的相容发现。
结论
新的诊断标准在血清阴性 NMOSD 中具有临床应用价值。
Zotero 插件