Kay Daniel B, Dombrovski Alexandre Y, Buysse Daniel J, Reynolds Charles F, Begley Amy, Szanto Katalin
Department of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
Int Psychogeriatr. 2016 Apr;28(4):613-9. doi: 10.1017/S104161021500174X. Epub 2015 Nov 10.
Insomnia increases in prevalence with age, is strongly associated with depression, and has been identified as a risk factor for suicide in several studies. The aim of this study was to determine whether insomnia severity varies between those who have attempted suicide (n = 72), those who only contemplate suicide (n = 28), and those who are depressed but have no suicidal ideation or attempt history (n = 35).
Participants were middle-aged and older adults (age 44-87, M = 66 years) with depression. Insomnia severity was measured as the sum of the early, middle, and late insomnia items from the Hamilton Rating Scale for Depression. General linear models examined relations between group status as the independent variable and insomnia severity as the dependent variable.
The suicide attempt group suffered from more severe insomnia than the suicidal ideation and non-suicidal depressed groups (p < 0.05). Differences remained after adjusting for potential confounders including demographics, cognitive ability, alcohol dependence in the past month, severity of depressed mood, anxiety, and physical health burden. Moreover, greater insomnia severity in the suicide attempt group could not be explained by interpersonal difficulties, executive functioning, benzodiazepine use, or by the presence of post-traumatic stress disorder.
Our results suggest that insomnia may be more strongly associated with suicidal behavior than with the presence of suicidal thoughts alone. Accordingly, insomnia is a potential treatment target for reducing suicide risk in middle-aged and older adults.
失眠患病率随年龄增长而上升,与抑郁症密切相关,并且在多项研究中已被确定为自杀的危险因素。本研究的目的是确定失眠严重程度在曾有自杀未遂行为者(n = 72)、仅考虑自杀者(n = 28)以及患有抑郁症但无自杀意念或自杀未遂史者(n = 35)之间是否存在差异。
参与者为患有抑郁症的中老年人(年龄44 - 87岁,平均年龄M = 66岁)。失眠严重程度通过汉密尔顿抑郁量表中早、中、晚失眠项目得分总和来衡量。采用一般线性模型检验以分组状态为自变量、失眠严重程度为因变量之间的关系。
自杀未遂组的失眠症状比有自杀意念组和无自杀意念的抑郁症组更为严重(p < 0.05)。在对包括人口统计学特征、认知能力、过去一个月的酒精依赖情况、抑郁情绪严重程度、焦虑以及身体健康负担等潜在混杂因素进行调整后,差异依然存在。此外,自杀未遂组更严重的失眠症状无法通过人际困难、执行功能、苯二氮䓬类药物使用情况或创伤后应激障碍的存在来解释。
我们的研究结果表明,失眠与自杀行为的关联可能比仅与自杀意念的关联更为紧密。因此,失眠是降低中老年人自杀风险的一个潜在治疗靶点。