Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France.
Rheumatology Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.
Autoimmun Rev. 2016 Feb;15(2):174-83. doi: 10.1016/j.autrev.2015.11.004. Epub 2015 Nov 7.
Extracellular vesicles (EVs) consist of exosomes released upon fusion of multivesicular bodies with the cell plasma membrane and microparticles shed directly from the cell membrane of many cell types. EVs can mediate cell-cell communication and are involved in many processes including inflammation, immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. Accumulating evidence reveals that EVs act in the establishment, maintenance and modulation of autoimmune processes among several others involved in cancer and cardiovascular complications. EVs could also present biomedical applications, as disease biomarkers and therapeutic targets or agents for drug delivery.
细胞外囊泡 (EVs) 由多泡体与细胞质膜融合时释放的外泌体和许多细胞类型的细胞膜直接脱落的微颗粒组成。EVs 可以介导细胞间通讯，并参与许多过程，包括炎症、免疫信号、血管生成、应激反应、衰老、增殖和细胞分化。越来越多的证据表明，EVs 在自身免疫过程的建立、维持和调节中发挥作用，在癌症和心血管并发症等其他疾病中也发挥作用。EVs 还具有生物医学应用的潜力，可作为疾病生物标志物和治疗靶点，或作为药物递送的载体。
Zotero 插件