糖通过与SCAP交流产生脂肪。
Sugar Makes Fat by Talking to SCAP.
作者信息
Shao Wei, Espenshade Peter J
机构信息
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Cancer Cell. 2015 Nov 9;28(5):548-549. doi: 10.1016/j.ccell.2015.10.011.
Abstract
Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.
摘要
血糖升高通过激活SREBP转录因子促进脂肪生成。肿瘤表现出葡萄糖摄取和脂肪生成增加，但其调控机制尚不清楚。在本期《癌细胞》杂志中，程等人发现葡萄糖通过稳定SCAP（SREBP途径的核心调节因子）来激活SREBP。
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