伊朗克尔曼地区艾滋病毒感染患者和地中海贫血患者中致泻性大肠杆菌的高感染率
High Frequency of Diarrheagenic Escherichia coli in HIV-Infected Patients and Patients with Thalassemia in Kerman, Iran.
作者信息
Alizade Hesam, Sharifi Hamid, Naderi Zahedeh, Ghanbarpour Reza, Bamorovat Mehdi, Aflatoonian Mohammad Reza
机构信息
1 Department of Microbiology, Sirjan Faculty of Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran.
2 Regional Knowledge Hub and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
J Int Assoc Provid AIDS Care. 2017 Jul/Aug;16(4):353-358. doi: 10.1177/2325957415617831. Epub 2015 Nov 20.
This study was conducted on patients with thalassemia and HIV-infected patients to determine the frequency of diarrheagenic Escherichia coli in Kerman, Iran. We analyzed 68 and 49 E coli isolates isolated from healthy fecal samples of patients with thalassemia and HIV-infected patients, respectively. The E coli isolates were studied using a multiplex polymerase chain reaction to identify the enterotoxigenic E coli (ETEC), enterohemorrhagic E coli (EHEC), and enteropathogenic E coli (EPEC) groups. Statistical analysis was carried out to determine the correlation of diarrheagenic E coli between HIV-infected patients and patients with thalassemia using Stata 11.2 software. The frequency of having at least 1 diarrheagenic E coli was more common in patients with thalassemia (67.64%) than in HIV-infected patients (57.14%; P = .25), including ETEC (67.64% versus 57.14%), EHEC (33.82% versus 26.53%), and EPEC (19.11% versus 16.32%). The results of this study indicate that ETEC, EHEC, and EPEC pathotypes are widespread among diarrheagenic E coli isolates in patients with thalassemia and HIV-infected patients.
本研究针对地中海贫血患者和HIV感染患者开展，以确定伊朗克尔曼地区致泻性大肠杆菌的感染率。我们分别分析了从地中海贫血患者和HIV感染患者的健康粪便样本中分离出的68株和49株大肠杆菌菌株。使用多重聚合酶链反应对大肠杆菌菌株进行研究，以鉴定产肠毒素大肠杆菌（ETEC）、肠出血性大肠杆菌（EHEC）和肠致病性大肠杆菌（EPEC）菌群。使用Stata 11.2软件进行统计分析，以确定HIV感染患者和地中海贫血患者中致泻性大肠杆菌的相关性。在地中海贫血患者中，至少感染1种致泻性大肠杆菌的发生率（67.64%）高于HIV感染患者（57.14%；P = 0.25），包括ETEC（67.64%对57.14%）、EHEC（33.82%对26.53%）和EPEC（19.11%对16.32%）。本研究结果表明，ETEC、EHEC和EPEC致病型在地中海贫血患者和HIV感染患者的致泻性大肠杆菌分离株中广泛存在。
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