基孔肯雅病毒在白纹伊蚊唾液腺中的复制
Chikungunya Virus Replication in Salivary Glands of the Mosquito Aedes albopictus.
作者信息
Vega-Rúa Anubis, Schmitt Christine, Bonne Isabelle, Krijnse Locker Jacomine, Failloux Anna-Bella
机构信息
Arboviruses and Insect Vectors Unit, Department of Virology, Institute Pasteur, 25-28 rue du Docteur Roux, 75724 Paris cedex 15, France.
Ultrapole, Center for Innovation and Technology Research, Institute Pasteur, 25-28 rue du Docteur Roux, 75724 Paris cedex 15, France.
出版信息
Viruses. 2015 Nov 17;7(11):5902-7. doi: 10.3390/v7112917.
Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standardized protocol to visualize viral particles in the mosquito salivary glands using transmission electron microscopy. Here we provide direct evidence for CHIKV replication and storage in Ae. albopictus salivary glands.
基孔肯雅病毒（CHIKV）是一种新兴的虫媒病毒，可通过白纹伊蚊等蚊子传播给人类。为了实现传播，CHIKV必须在蚊子中肠内复制，然后在血腔中扩散并感染唾液腺，之后才能通过唾液释放出来。我们已经开发出一种标准化方案，利用透射电子显微镜观察蚊子唾液腺中的病毒颗粒。在此，我们提供了基孔肯雅病毒在白纹伊蚊唾液腺中复制和储存的直接证据。
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