Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
J Immunol Res. 2015;2015:817604. doi: 10.1155/2015/817604. Epub 2015 Oct 29.
Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation. Chemotaxis is mediated by the G protein-coupled receptor (GPCR) signaling pathway. Extracellular stimuli trigger activation of the PLC/PKC/PKD signaling axis, which controls several signaling pathways. Here, we concentrate on the novel functions of PLC/PKC/PKD signaling in GPCR-mediated chemotaxis of neutrophils.
趋化作用，即细胞在细胞外化学趋化物浓度梯度引导下的定向迁移，在中性粒细胞向炎症部位募集中发挥重要作用。趋化作用由 G 蛋白偶联受体（GPCR）信号通路介导。细胞外刺激触发 PLC/PKC/PKD 信号轴的激活，该信号轴控制着几种信号通路。在这里，我们专注于 PLC/PKC/PKD 信号在 GPCR 介导的中性粒细胞趋化作用中的新功能。
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