基于蛋白质自组装的超疏水表面及其在蛋白质结晶方面的新兴应用。
A Superhydrophobic Surface Templated by Protein Self-Assembly and Emerging Application toward Protein Crystallization.
机构信息
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.
State Key Laboratory of Supramolecular Structure, Jilin University, Changchun, 130012, China.
出版信息
Adv Mater. 2016 Jan 20;28(3):579-87. doi: 10.1002/adma.201504769. Epub 2015 Nov 26.
A proteinaceous superhydrophobic material for facile protein crystallization is reported. The lysozyme phase transition is rationally manipulated to form a reliable superhydrophobic coating on virtually arbitrary material surfaces with good thermostability and mechanical robustness. Such a surface exhibits a fascinating capability to drive protein crystallization, and the protein crystal array can be facilitated in a large area at an ultralow protein concentration.
本文报道了一种用于蛋白质结晶的蛋白质超疏水材料。通过合理调控溶菌酶的相转变，在几乎任意材料表面形成可靠的超疏水涂层，具有良好的热稳定性和机械鲁棒性。这种表面具有驱动蛋白质结晶的迷人能力，并且可以在超低蛋白质浓度下在大面积上促进蛋白质晶体阵列的形成。
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