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沙特阿拉伯人群睡眠时间与代谢综合征心血管代谢危险因素之间的关联。

Association between sleeping hours and cardiometabolic risk factors for metabolic syndrome in a Saudi Arabian population.

作者信息

Brocato Jason, Wu Fen, Chen Yu, Shamy Magdy, Alghamdi Mansour A, Khoder Mamdouh I, Alkhatim Alser A, Abdou Mamdouh H, Costa Max

机构信息

Department of Environmental Medicine, NYU School of Medicine, New York, New York, USA.

Department of Population Health, NYU School of Medicine, New York, New York, USA.

出版信息

BMJ Open. 2015 Nov 30;5(11):e008590. doi: 10.1136/bmjopen-2015-008590.

Abstract

OBJECTIVES

Epidemiological and molecular studies have shown that sleep duration is associated with metabolic syndrome (MtS), a disease that is on the rise in the Kingdom of Saudi Arabia. We aim to investigate the association between sleep duration and selected cardiometabolic risk factors of MtS in a Saudi Arabian population.

SETTING

Secondary care was given to the participants. There were 2 participating centres, shopping malls in North and South Jeddah, Saudi Arabia.

PARTICIPANTS

We recruited 2686 participants over a 1-year study period. Participants were selected based on their willingness. The only criterion for exclusion was living in the area (North or South Jeddah) for less than 15 years.

PLANNED AND PRIMARY OUTCOME MEASURES

Participants were measured for blood sugar levels, blood pressure and body mass index. All participants were asked to fill out a questionnaire.

RESULTS

There was a positive association between longer sleep duration and obesity, hypertension and hyperglycaemia. The adjusted ORs for obesity, hypertension and hyperglycaemia were 1.54 (95% CI 1.20 to 1.98), 1.89 (95% CI 1.45 to 2.48) and 1.59 (95% CI 1.19 to 2.13), respectively, in participants sleeping >8 h/night, as compared with those sleeping 7 h. The positive associations between longer sleep duration, defined as sleeping >7 h, and the disease status, did not differ from other risk factors such as physical activity and nutrition.

CONCLUSIONS

This is the first epidemiological study reporting on the association between sleep duration and cardiometabolic risk factors of MtS in a Saudi Arabian population. Sleep durations of 8 h or greater were found to be associated with all 3 cardiometabolic risk factors: obesity, hypertension and hyperglycaemia, and this relationship was not confounded by quality of nutrition or physical activity levels.

摘要

目的

流行病学和分子研究表明,睡眠时间与代谢综合征(MtS)有关,而代谢综合征在沙特阿拉伯王国呈上升趋势。我们旨在调查沙特人群中睡眠时间与MtS选定的心脏代谢危险因素之间的关联。

设置

为参与者提供二级护理。有2个参与中心,分别是沙特阿拉伯吉达北部和南部的购物中心。

参与者

在为期1年的研究期间,我们招募了2686名参与者。参与者根据其意愿进行选择。唯一的排除标准是在该地区(吉达北部或南部)居住少于15年。

计划和主要结局指标

测量参与者的血糖水平、血压和体重指数。所有参与者都被要求填写一份问卷。

结果

较长的睡眠时间与肥胖、高血压和高血糖之间存在正相关。与每晚睡眠7小时的参与者相比,每晚睡眠超过8小时的参与者肥胖、高血压和高血糖的校正比值比分别为1.54(95%CI 1.20至1.98)、1.89(95%CI 1.45至2.48)和1.59(95%CI 1.19至2.13)。睡眠时间较长(定义为睡眠>7小时)与疾病状态之间的正相关与身体活动和营养等其他危险因素没有差异。

结论

这是第一项关于沙特人群中睡眠时间与MtS心脏代谢危险因素之间关联的流行病学研究。发现8小时或更长时间的睡眠时间与所有3种心脏代谢危险因素相关:肥胖、高血压和高血糖,并且这种关系不受营养质量或身体活动水平的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7fe/4679834/948803735e4e/bmjopen2015008590f01.jpg

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