Jonasson O
Department of Surgery, Ohio State University College of Medicine, Columbus.
Transplant Proc. 1989 Jun;21(3):3390-4; discussion 3413-8.
Assuring equitable access of patients to needed organ transplants is a responsibility that must be shared by transplantation teams, the patients, their families, referring physicians, and society as a whole. Barriers of major proportion still exist that strongly bias the initial selection of patients for placement on waiting lists and adversely affect the rates of transplantation among the older age groups, nonwhites, and the poor. The very issue of making up the waiting list is fundamental to the development of fair and equitable distribution of the national resource of organs for transplantation. Actual organ allocation must involve medical judgment and must strive to achieve the maximal benefit to patients. Despite dangers of paternalism and bias masquerading as medical criteria, to overlook outcome predictions in selecting the recipient of a scarce resource is to be irresponsible toward the donor and society as well as to the patients on the list. Insofar as benefit and need can both be served, as in the case of liver transplantation for fulminant liver failure or kidney transplantation in a well-matched recipient, these considerations should far outweigh the poor criterion of length of time on the waiting list. In many instances, it will be the most appropriate choice to give the organ to a patient waiting on the list at home rather than to a desperately ill patient who will doubtlessly die without the operation but whose risks of failure are significantly higher. As difficult as these decisions are, especially in life and death situations, a system of organ allocation based on medical judgment, with appropriate safeguards and thorough monitoring, eventually will prove to be the fairest method.
确保患者能够公平地获得所需的器官移植是移植团队、患者及其家属、转诊医生以及整个社会共同承担的责任。仍然存在着很大比例的障碍,这些障碍严重影响了对等待名单上患者的初步筛选,并对老年人群体、非白人以及贫困人口的移植率产生了不利影响。编制等待名单这一问题对于公平合理地分配国家移植器官资源至关重要。实际的器官分配必须包含医学判断,并且必须努力为患者实现最大利益。尽管存在家长式作风以及将偏见伪装成医学标准的风险,但在选择稀缺资源的接受者时忽视预后预测,对于捐赠者、社会以及等待名单上的患者都是不负责任的。只要能够兼顾受益和需求,比如在暴发性肝衰竭患者进行肝移植或在配型良好的受者中进行肾移植的情况下,这些考量应远远超过在等待名单上的时间这一欠佳标准。在许多情况下,将器官给予在家中等待名单上的患者,而不是给予一个不进行手术无疑会死亡但手术失败风险明显更高的重症患者,将是最合适的选择。尽管这些决定非常困难,尤其是在生死攸关的情况下,但基于医学判断、有适当保障措施和全面监测的器官分配系统最终将被证明是最公平的方法。