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机器人辅助与腹腔镜下早期宫颈癌根治性宫颈切除术:病例报告及文献综述

Robotic Versus Laparoscopic Radical Trachelectomy for Early-Stage Cervical Cancer: Case Report and Review of Literature.

作者信息

Api Murat, Boza Aysen, Ceyhan Mehmet

机构信息

Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Training and Research Hospital, Van Turkey.

Van Ipekyolu Women and Children Diseases Hospital, Van, Turkey.

出版信息

J Minim Invasive Gynecol. 2016 Jul-Aug;23(5):677-83. doi: 10.1016/j.jmig.2015.11.009. Epub 2015 Nov 26.

Abstract

We conducted a literature review to evaluate the minimally invasive fertility-sparing procedures, namely robotic radical trachelectomy (RRT) and laparoscopic radical trachelectomy (LRT), in patients with early-stage cervical cancer. We searched PubMed, MEDLINE, Ovid, Google Scholar, and Scopus up to July 2015 using the following key words and their combinations: cervical cancer, early stage, fertility-sparing surgery, radical trachelectomy, robotic trachelectomy, and laparoscopic trachelectomy. Papers providing details of RRT and LRT separately were included. Extracted papers and their bibliographies were reviewed according to the purpose of the study, and demographic, surgical, and clinical parameters were analyzed. Our review comprised 45 cases of RRT and 216 cases (including our case) of LRT. The median (range) patient age was 29 (9) years in the RRT group and 32 (10) years in the LRT group (p < .001). Histological types and stages were significantly different in the 2 groups (p < .001 for both). The median length of excised parametrial tissue was significantly higher in the RRT group (p < .001). The hysterectomy conversion rate on the results of frozen section examination was significantly higher in the RRT group (37% vs 6.5%; p < .001). There was a significant difference in median lymph node count based on the surgical approach (RRT: 22 [range, 21] vs LRT: 32 [range, 14]; p = .02). Estimated blood loss and length of hospital stay were significantly higher in the LRT group (both p < .001). The mean (range) operative time was 308 (188) minutes in the RRT group and 296 (143) minutes in the LRT group (p < .001). Pregnancy, preterm, and term birth rates were similar in the 2 groups (RRT: 18.5%, 7.4%, and 0, respectively; LRT: 29%, 8%, and 8%, respectively). Thirteen women experienced recurrent cervical cancer in the LRT group, and no recurrence was seen in the RRT group. The median (range) duration of follow-up was 8 (7.5) months in the RRT group and 34 (20) months in the LRT group (p < .001). Based on the reported data, LRT seems comparable to RRT for treating patients with early-stage cervical cancer who wish to preserve fertility.

摘要

我们进行了一项文献综述,以评估早期宫颈癌患者的微创保留生育功能手术,即机器人根治性宫颈切除术(RRT)和腹腔镜根治性宫颈切除术(LRT)。截至2015年7月,我们使用以下关键词及其组合在PubMed、MEDLINE、Ovid、谷歌学术和Scopus中进行了检索:宫颈癌、早期、保留生育功能手术、根治性宫颈切除术、机器人宫颈切除术和腹腔镜宫颈切除术。分别提供RRT和LRT详细信息的论文被纳入。根据研究目的对提取的论文及其参考文献进行了综述,并分析了人口统计学、手术和临床参数。我们的综述包括45例RRT病例和216例(包括我们的病例)LRT病例。RRT组患者年龄中位数(范围)为29(9)岁,LRT组为32(10)岁(p<0.001)。两组的组织学类型和分期有显著差异(两者p<0.001)。RRT组切除的宫旁组织中位数长度显著更高(p<0.001)。根据冰冻切片检查结果,RRT组子宫切除术转化率显著更高(37%对6.5%;p<0.001)。基于手术方式的中位淋巴结计数有显著差异(RRT:22[范围,21]对LRT:32[范围,14];p=0.02)。LRT组估计失血量和住院时间显著更高(两者p<0.001)。RRT组平均(范围)手术时间为308(188)分钟,LRT组为296(143)分钟(p<0.001)。两组的妊娠、早产和足月产率相似(RRT组分别为18.5%、7.4%和0;LRT组分别为29%、8%和8%)。LRT组有13名女性发生复发性宫颈癌,RRT组未见复发。RRT组随访时间中位数(范围)为8(7.5)个月,LRT组为34(20)个月(p<0.001)。根据报告的数据,对于希望保留生育功能的早期宫颈癌患者,LRT似乎与RRT相当。

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