Jones Kevin C, Vander Stappen François, Bawiec Christopher R, Janssens Guillaume, Lewin Peter A, Prieels Damien, Solberg Timothy D, Sehgal Chandra M, Avery Stephen
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Ion Beam Applications SA, Louvain-la-Neuve 1348, Belgium.
Med Phys. 2015 Dec;42(12):7090-7. doi: 10.1118/1.4935865.
To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron.
An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam.
The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current.
The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.
测量医院临床回旋加速器产生的脉冲质子束流所产生的声信号。
使用电子函数发生器对IBA C230等时性回旋加速器进行调制,以产生脉冲质子束。利用水听器在水中测量质子束产生的声发射。随着质子电流增加以及探测器与束流之间距离增加,重复进行声学测量。
回旋加速器产生的质子束流上升时间为18 μs,测得的最大瞬时质子电流为790 nA。质子能量沉积产生的声发射测量值约为mPa量级。基于声发射到达时间与水听器和质子束之间距离的相关性,确定声波起源于质子束。声频谱在10 kHz处达到峰值,声压幅值随质子电流增加而单调增加。
作者首次报道了医院临床回旋加速器产生的质子束流所产生的声发射。当由电子函数发生器调制时,回旋加速器能够产生上升时间快(18 μs)和瞬时电流高(790 nA)的质子束流。在临床环境中对质子产生的声发射进行测量可能为体内质子射程验证和患者监测提供一种方法。